PT  - JOURNAL ARTICLE
AU  - Bala, F.
AU  - Ospel, J.
AU  - Mulpur, B.
AU  - Kim, B.J.
AU  - Yoo, J.
AU  - Menon, B.K.
AU  - Goyal, M.
AU  - Federau, C.
AU  - Sohn, S.-I.
AU  - Hussain, M.S.
AU  - Almekhlafi, M.A.
TI  - Infarct Growth despite Successful Endovascular Reperfusion in Acute Ischemic Stroke: A Meta-analysis
AID  - 10.3174/ajnr.A7177
DP  - 2021 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1472--1478
VI  - 42
IP  - 8
4099  - http://www.ajnr.org/content/42/8/1472.short
4100  - http://www.ajnr.org/content/42/8/1472.full
SO  - Am. J. Neuroradiol.2021 Aug 01; 42
AB  - BACKGROUND: Infarct volume inversely correlates with good recovery in stroke. The magnitude and predictors of infarct growth despite successful reperfusion via endovascular treatment are not known.PURPOSE: We aimed to summarize the extent of infarct growth in patients with acute stroke who achieved successful reperfusion (TICI 2b–3) after endovascular treatment.DATA SOURCES: We performed a systematic review and meta-analysis by searching MEDLINE and Google Scholar for articles published up to October 31, 2020.STUDY SELECTION: Studies of >10 patients reporting baseline and post-endovascular treatment infarct volumes on MR imaging were included. Only patients with TICI 2b–3 were included. We calculated infarct growth at a study level as the difference between baseline and follow-up MR imaging infarct volumes.DATA ANALYSIS: Our search yielded 345 studies, and we included 10 studies reporting on 973 patients having undergone endovascular treatment who achieved successful reperfusion.DATA SYNTHESIS: The mean baseline infarct volume was 19.5 mL, while the mean final infarct volume was 37.5 mL. A TICI 2b reperfusion grade was achieved in 24% of patients, and TICI 2c or 3 in 76%. The pooled mean infarct growth was 14.8 mL (95% CI, 7.9–21.7 mL). Meta-regression showed higher infarct growth in studies that reported higher baseline infarct volumes, higher rates of incomplete reperfusion (modified TICI 2b), and longer onset-to-reperfusion times.LIMITATIONS: Significant heterogeneity among studies was noted and might be driven by the difference in infarct growth between early- and late-treatment studies.CONCLUSIONS: These results suggest considerable infarct growth despite successful endovascular treatment reperfusion and call for a faster workflow and the need for specific therapies to limit infarct growth.EVTendovascular treatmentmTICImodified TICI