PT  - JOURNAL ARTICLE
AU  - Chang, W.
AU  - Landgraf, B.
AU  - Johnson, K.M.
AU  - Kecskemeti, S.
AU  - Wu, Y.
AU  - Velikina, J.
AU  - Rowley, H.
AU  - Wieben, O.
AU  - Mistretta, C.
AU  - Turski, P.
TI  - Velocity Measurements in the Middle Cerebral Arteries of Healthy Volunteers Using 3D Radial Phase-Contrast HYPRFlow: Comparison with Transcranial Doppler Sonography and 2D Phase-Contrast MR Imaging
AID  - 10.3174/ajnr.A2240
DP  - 2011 Jan 01
TA  - American Journal of Neuroradiology
PG  - 54--59
VI  - 32
IP  - 1
4099  - http://www.ajnr.org/content/32/1/54.short
4100  - http://www.ajnr.org/content/32/1/54.full
SO  - Am. J. Neuroradiol.2011 Jan 01; 32
AB  - BACKGROUND AND PURPOSE: We have developed PC HYPRFlow, a comprehensive MRA technique that includes a whole-brain CE dynamic series followed by PC velocity-encoding, yielding a time series of high-resolution morphologic angiograms with associated velocity information. In this study, we present velocity data acquired by using the PC component of PC HYPRFlow (PC-VIPR). MATERIALS AND METHODS: Ten healthy volunteers (6 women, 4 men) were scanned by using PC HYPRFlow and 2D-PC imaging, immediately followed by velocity measurements by using TCD. Velocity measurements were made in the M1 segments of the MCAs from the PC-VIPR, 2D-PC, and TCD examinations. RESULTS: PC-VIPR showed approximately 30% lower mean velocity compared with TCD, consistent with other comparisons of TCD with PC-MRA. The correlation with TCD was r = 0.793, and the correlation of PC-VIPR with 2D-PC was r = 0.723. CONCLUSIONS: PC-VIPR is a technique capable of acquiring high-resolution MRA of diagnostic quality with velocity data comparable with TCD and 2D-PC. The combination of velocity information and fast high-resolution whole-brain morphologic angiograms makes PC HYPRFlow an attractive alternative to current MRA methods. CEcontrast-enhancedCE-VIPRcontrast-enhanced vastly undersampled isotropic projection reconstruction2D-PC2D phase-contrastHYPR-LRhighly constrained local projection reconstructionMCAmiddle cerebral arteryMRAMR angiographyPCphase-contrastPC HYPRFlowtime-resolved MRA using highly constrained projection reconstruction and PC-VIPR data for the reconstruction convolutionPC-MRAphase-contrast MR angiographyPC-VIPRphase-contrast vastly undersampled isotropic projection reconstructionSNRsignal intensity–to-noise ratioTCDtranscranial Doppler sonographyVENCvelocity encodingWSSwall shear stress