RT Journal Article
SR Electronic
T1 Quantitative and Qualitative Comparison of 4D-DSA with 3D-DSA Using Computational Fluid Dynamics Simulations in Cerebral Aneurysms
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1505
OP 1510
DO 10.3174/ajnr.A6172
VO 40
IS 9
A1 Lang, S.
A1 Hoelter, P.
A1 Birkhold, A.I.
A1 Schmidt, M.
A1 Endres, J.
A1 Strother, C.
A1 Doerfler, A.
A1 Luecking, H.
YR 2019
UL http://www.ajnr.org/content/40/9/1505.abstract
AB BACKGROUND AND PURPOSE: 4D-DSA allows time-resolved 3D imaging of the cerebral vasculature. The aim of our study was to evaluate this method in comparison with the current criterion standard 3D-DSA by qualitative and quantitative means using computational fluid dynamics.MATERIALS AND METHODS: 3D- and 4D-DSA datasets were acquired in patients with cerebral aneurysms. Computational fluid dynamics analysis was performed for all datasets. Using computational fluid dynamics, we compared 4D-DSA with 3D-DSA in terms of both aneurysmal geometry (quantitative: maximum diameter, ostium size [OZ1/2], volume) and hemodynamic parameters (qualitative: flow stability, flow complexity, inflow concentration; quantitative: average/maximum wall shear stress, impingement zone, low-stress zone, intra-aneurysmal pressure, and flow velocity). Qualitative parameters were descriptively analyzed. Correlation coefficients (r, P value) were calculated for quantitative parameters.RESULTS: 3D- and 4D-DSA datasets of 10 cerebral aneurysms in 10 patients were postprocessed. Evaluation of aneurysmal geometry with 4D-DSA (rmaximum diameter = 0.98, Pmaximum diameter <.001; rOZ1/OZ2 = 0.98/0.86, POZ1/OZ2 < .001/.002; rvolume = 0.98, Pvolume <.001) correlated highly with 3D-DSA. Evaluation of qualitative hemodynamic parameters (flow stability, flow complexity, inflow concentration) did show complete accordance, and evaluation of quantitative hemodynamic parameters (raverage/maximum wall shear stress diastole = 0.92/0.88, Paverage/maximum wall shear stress diastole < .001/.001; raverage/maximum wall shear stress systole = 0.94/0.93, Paverage/maximum wall shear stress systole < .001/.001; rimpingement zone = 0.96, Pimpingement zone < .001; rlow-stress zone = 1.00, Plow-stress zone = .01; rpressure diastole = 0.84, Ppressure diastole = .002; rpressure systole = 0.9, Ppressure systole < .001; rflow velocity diastole = 0.95, Pflow velocity diastole < .001; rflow velocity systole = 0.93, Pflow velocity systole < .001) did show nearly complete accordance between 4D- and 3D-DSA.CONCLUSIONS: Despite a different injection protocol, 4D-DSA is a reliable basis for computational fluid dynamics analysis of the intracranial vasculature and provides equivalent visualization of aneurysm geometry compared with 3D-DSA.AWSSaverage wall shear stressCFDcomputational fluid dynamicsdmaxmaximum diameterIZimpingement zoneLSZlow-stress zoneMWSSmaximum wall shear stressOZostium sizercorrelation coefficientVflow velocityWSSwall shear stress