PT  - JOURNAL ARTICLE
AU  - Lasocki, A.
AU  - Gaillard, F.
TI  - Non-Contrast-Enhancing Tumor: A New Frontier in Glioblastoma Research
AID  - 10.3174/ajnr.A6025
DP  - 2019 May 01
TA  - American Journal of Neuroradiology
PG  - 758--765
VI  - 40
IP  - 5
4099  - http://www.ajnr.org/content/40/5/758.short
4100  - http://www.ajnr.org/content/40/5/758.full
SO  - Am. J. Neuroradiol.2019 May 01; 40
AB  - SUMMARY: There is a growing understanding of the prognostic importance of non-contrast-enhancing tumor in glioblastoma, and recent attempts at more aggressive management of this component using neurosurgical resection and radiosurgery have been shown to prolong survival. Optimizing these therapeutic strategies requires an understanding of the features that can distinguish non-contrast-enhancing tumor from other processes, in particular vasogenic edema; however, the limited and heterogeneous manner in which it has been defined in the literature limits clinical translation. This review covers pertinent literature on our growing understanding of non-contrast-enhancing tumor and focuses on key conventional MR imaging features for improving its delineation. Such features include subtle differences in the degree of FLAIR hyperintensity, gray matter involvement, and focal mass effect. Improved delineation of tumor from edema will facilitate more aggressive management of this component and potentially realize associated survival benefits.CETcontrast-enhancing tumorFET[18F]-fluoroethyl-L-tyrosineGBMglioblastomanCETnon-contrast-enhancing tumor