PT - JOURNAL ARTICLE AU - Valand, H.A. AU - Huda, F. AU - Tu, R.K. TI - Chimeric Antigen Receptor T-Cell Therapy: What the Neuroradiologist Needs to Know AID - 10.3174/ajnr.A6042 DP - 2019 May 02 TA - American Journal of Neuroradiology 4099 - http://www.ajnr.org/content/early/2019/04/25/ajnr.A6042.short 4100 - http://www.ajnr.org/content/early/2019/04/25/ajnr.A6042.full AB - SUMMARY: Chimeric antigen receptor T-cell therapy is an exciting and rapidly emerging “fifth pillar” treatment for hematologic cancers. Unique treatment-related toxicities and cost remain a major hindrance to its widespread application. The commonly faced challenges with this innovative therapy, its neurotoxicity, and manifestation on neuroimaging studies, are reviewed.CARchimeric antigen receptorCRScytokine release syndromeCRESCAR-T-cell–related encephalopathy syndrome