PT  - JOURNAL ARTICLE
AU  - Spyris, C.D.
AU  - Castellino, R.C.
AU  - Schniederjan, M.J.
AU  - Kadom, N.
TI  - High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases
AID  - 10.3174/ajnr.A5888
DP  - 2019 Feb 01
TA  - American Journal of Neuroradiology
PG  - 366--369
VI  - 40
IP  - 2
4099  - http://www.ajnr.org/content/40/2/366.short
4100  - http://www.ajnr.org/content/40/2/366.full
SO  - Am. J. Neuroradiol.2019 Feb 01; 40
AB  - SUMMARY: High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.HGGhigh-grade gliomaLGGlow-grade gliomaNF1neurofibromatosis type 1