RT Journal Article
SR Electronic
T1 Progressive Multifocal Leukoencephalopathy: Serial High-b-Value Diffusion-Weighted MR Imaging and Apparent Diffusion Coefficient Measurements to Assess Response to Highly Active Antiretroviral Therapy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 285
OP 286
VO 28
IS 2
A1 Usiskin, S.I.
A1 Bainbridge, A.
A1 Miller, R.F.
A1 Jäger, H.R.
YR 2007
UL http://www.ajnr.org/content/28/2/285.abstract
AB SUMMARY: A patient with human immunodeficiency virus–related posterior fossa progressive multifocal leukoencephalopathy had serial diffusion-weighted imaging using b-values of 1000 and 3000 before and during highly active antiretroviral therapy (HAART). High-b-value images provided a superior definition of the leading edge of the lesion and additional information about the integrity of white matter tracts. Following HAART, there was a marked reduction of lesional apparent diffusion coefficient and reconstitution of anisotropy in the affected middle cerebellar peduncle.