RT Journal Article
SR Electronic
T1 Demyelinating and gliotic cerebellar lesions in Langerhans cell histiocytosis.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1921
OP 1928
VO 15
IS 10
A1 Poe, L B
A1 Dubowy, R L
A1 Hochhauser, L
A1 Collins, G H
A1 Crosley, C J
A1 Kanzer, M D
A1 Oliphant, M
A1 Hodge, C J
YR 1994
UL http://www.ajnr.org/content/15/10/1921.abstract
AB PURPOSE To describe the involvement of the cerebellum by a gliotic and demyelinating process in Langerhans cell histiocytosis. METHODS A retrospective analysis of all (N = 30) cases of Langerhans cell histiocytosis followed at our institution since 1975 yielded four patients with CT and/or MR evidence of cerebellar abnormalities. RESULTS Four patients manifested strikingly similar findings of symmetric nonenhancing hypodensities in the dentate nuclei region of the cerebellum, which were hypointense on short-repetition-time/short-echo-time MR and hyperintense on long-repetition-time/long-echo-time MR. Biopsy in one patient yielded areas of demyelination, cell loss, and gliosis without histiocytic infiltration. CONCLUSION Langerhans cell histiocytosis involves the cerebellum in a specific and poorly understood manner. Lesions on imaging may precede clinical findings by years. Lesions may occur in patients who have never experienced radiation therapy and may act as a marker for eventual central nervous system deterioration.