PT  - JOURNAL ARTICLE
AU  - Poe, L B
AU  - Dubowy, R L
AU  - Hochhauser, L
AU  - Collins, G H
AU  - Crosley, C J
AU  - Kanzer, M D
AU  - Oliphant, M
AU  - Hodge, C J
TI  - Demyelinating and gliotic cerebellar lesions in Langerhans cell histiocytosis.
DP  - 1994 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1921--1928
VI  - 15
IP  - 10
4099  - http://www.ajnr.org/content/15/10/1921.short
4100  - http://www.ajnr.org/content/15/10/1921.full
SO  - Am. J. Neuroradiol.1994 Nov 01; 15
AB  - PURPOSE To describe the involvement of the cerebellum by a gliotic and demyelinating process in Langerhans cell histiocytosis. METHODS A retrospective analysis of all (N = 30) cases of Langerhans cell histiocytosis followed at our institution since 1975 yielded four patients with CT and/or MR evidence of cerebellar abnormalities. RESULTS Four patients manifested strikingly similar findings of symmetric nonenhancing hypodensities in the dentate nuclei region of the cerebellum, which were hypointense on short-repetition-time/short-echo-time MR and hyperintense on long-repetition-time/long-echo-time MR. Biopsy in one patient yielded areas of demyelination, cell loss, and gliosis without histiocytic infiltration. CONCLUSION Langerhans cell histiocytosis involves the cerebellum in a specific and poorly understood manner. Lesions on imaging may precede clinical findings by years. Lesions may occur in patients who have never experienced radiation therapy and may act as a marker for eventual central nervous system deterioration.