RT Journal Article
SR Electronic
T1 What Have We Learned from Perfusion MRI in Multiple Sclerosis?
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 994
OP 1000
DO 10.3174/ajnr.A5504
VO 39
IS 6
A1 Lapointe, E.
A1 Li, D.K.B.
A1 Traboulsee, A.L.
A1 Rauscher, A.
YR 2018
UL http://www.ajnr.org/content/39/6/994.abstract
AB SUMMARY: Using MR imaging, perfusion can be assessed either by dynamic susceptibility contrast MR imaging or arterial spin-labeling. Alterations of cerebral perfusion have repeatedly been described in multiple sclerosis compared with healthy controls. Acute lesions exhibit relative hyperperfusion in comparison with normal-appearing white matter, a finding mostly attributed to inflammation in this stage of lesion development. In contrast, normal-appearing white and gray matter of patients with MS has been mostly found to be hypoperfused compared with controls, and correlations with cognitive impairment as well as fatigue in multiple sclerosis have been described. Mitochondrial failure, axonal degeneration, and vascular dysfunction have been hypothesized to underlie the perfusion MR imaging findings. Clinically, perfusion MR imaging could allow earlier detection of the acute focal inflammatory changes underlying relapses and new lesions, and could constitute a marker for cognitive dysfunction in MS. Nevertheless, the clinical relevance and pathogenesis of the brain perfusion changes in MS remain to be clarified.ASLarterial spin-labelingDCEdynamic contrast-enhancedNAWMnormal-appearing white matterRRMSrelapsing-remitting MS