RT Journal Article SR Electronic T1 Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 830 OP 833 DO 10.3174/ajnr.A5594 VO 39 IS 5 A1 Nguyen, T.D. A1 Zhang, S. A1 Gupta, A. A1 Zhao, Y. A1 Gauthier, S.A. A1 Wang, Y. YR 2018 UL http://www.ajnr.org/content/39/5/830.abstract AB SUMMARY: We developed a robust automated algorithm called statistical detection of changes for detecting morphologic changes of multiple sclerosis lesions between 2 T2-weighted FLAIR brain images. Results from 30 patients showed that statistical detection of changes achieved significantly higher sensitivity and specificity (0.964, 95% CI, 0.823–0.994; 0.691, 95% CI, 0.612–0.761) than with the lesion-prediction algorithm (0.614, 95% CI, 0.410–0.784; 0.281, 95% CI, 0.228–0.314), while resulting in a 49% reduction in human review time (P = .007).LPAlesion prediction algorithmSDCstatistical detection of changes