PT  - JOURNAL ARTICLE
AU  - de Boysson, H.
AU  - Boulouis, G.
AU  - Parienti, J.-J.
AU  - Touzé, E.
AU  - Zuber, M.
AU  - Arquizan, C.
AU  - Dequatre, N.
AU  - Detante, O.
AU  - Bienvenu, B.
AU  - Aouba, A.
AU  - Guillevin, L.
AU  - Pagnoux, C.
AU  - Naggara, O.
TI  - Concordance of Time-of-Flight MRA and Digital Subtraction Angiography in Adult Primary Central Nervous System Vasculitis
AID  - 10.3174/ajnr.A5300
DP  - 2017 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1917--1922
VI  - 38
IP  - 10
4099  - http://www.ajnr.org/content/38/10/1917.short
4100  - http://www.ajnr.org/content/38/10/1917.full
SO  - Am. J. Neuroradiol.2017 Oct 01; 38
AB  - BACKGROUND AND PURPOSE: 3D-TOF-MRA and DSA are 2 available tools to demonstrate neurovascular involvement in primary central nervous system vasculitis. We aimed to compare the diagnostic concordance of vessel imaging using 3D-TOF-MRA and DSA in patients with primary central nervous system vasculitis.MATERIALS AND METHODS: We retrospectively identified all patients included in the French primary central nervous system vasculitis cohort of 85 patients who underwent, at baseline, both intracranial 3D-TOF-MRA and DSA in an interval of no more than 2 weeks and before treatment initiation. Two neuroradiologists independently reviewed all 3D-TOF-MRA and DSA imaging. Brain vasculature was divided into 25 arterial segments. Concordance between 3D-TOF-MRA and DSA for the identification of arterial stenosis was assessed by the Cohen κ Index.RESULTS: Thirty-one patients met the inclusion criteria, including 20 imaged with a 1.5T MR unit and 11 with a 3T MR unit. Among the 25 patients (81%) with abnormal DSA findings, 24 demonstrated abnormal 3D-TOF-MRA findings, whereas all 6 remaining patients with normal DSA findings had normal 3D-TOF-MRA findings. In the per-segment analysis, concordance between 1.5T 3D-TOF-MRA and DSA was 0.82 (95% CI, 0.75–0.93), and between 3T 3D-TOF-MRA and DSA, it was 0.87 (95% CI, 0.78–0.91).CONCLUSIONS: 3D-TOF-MRA shows a high concordance with DSA in diagnostic performance when analyzing brain vasculature in patients with primary central nervous system vasculitis. In patients with negative 3T 3D-TOF-MRA findings, the added diagnostic value of DSA is limited.COVACCOhort of patients with primary VAsculitis of the Central nervous systemPCNSVprimary central nervous system vasculitisRCVSreversible cerebral vasoconstriction syndromeSCAsuperior cerebellar artery