PT  - JOURNAL ARTICLE
AU  - Numaguchi, Y
AU  - Weems, A M
AU  - Mizushima, A
AU  - Keating, J
AU  - Rege, A B
AU  - Mather, F J
AU  - Rice, J C
TI  - Myelography with metrizamide: effect of contrast removal on side effects.
DP  - 1986 May 01
TA  - American Journal of Neuroradiology
PG  - 498--501
VI  - 7
IP  - 3
4099  - http://www.ajnr.org/content/7/3/498.short
4100  - http://www.ajnr.org/content/7/3/498.full
SO  - Am. J. Neuroradiol.1986 May 01; 7
AB  - Moderately severe side effects, such as prolonged headache, nausea, vomiting, or psychoneurologic symptoms, were noted in 27 (32%) of 84 patients in whom the contrast medium was not removed. Conversely, among 73 patients from whom 20-25 ml of cerebrospinal fluid with the contrast medium was removed, only 10 (14%) experienced adverse effects, a statistically significant reduction. Although new contrast agents, such as iohexol and iopamidol, are reportedly less toxic than metrizamide, the contrast-removal technique described here may be indicated when large amounts of any contrast medium are used.