RT Journal Article
SR Electronic
T1 Cerebral complications of murine monoclonal CD3 antibody (OKT3): CT and MR findings.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1935
OP 1938
VO 18
IS 10
A1 Parizel, P M
A1 Snoeck, H W
A1 van den Hauwe, L
A1 Boven, K
A1 Bosmans, J L
A1 Van Goethem, J W
A1 Van Marck, E A
A1 Cras, P
A1 De Schepper, A M
A1 De Broe, M E
YR 1997
UL http://www.ajnr.org/content/18/10/1935.abstract
AB Treatment of acute renal allograft rejection with mouse monoclonal antibody (OKT3) is associated with systemic and neurologic side effects. We describe cerebral abnormalities in a 13-year-old boy with steroid-resistant renal allograft rejection. After treatment with OKT3, an acute neurologic syndrome developed, including seizures, lethargy, and decreased mental function. CT and MR imaging revealed confluent cerebral lesions at the corticomedullary junction. Contrast-enhanced MR images showed patchy enhancement, indicating blood-brain barrier dysfunction. The diagnosis of OKT3-induced encephalopathy with cerebral edema and capillary leak syndrome was made. Although CT and MR findings are nonspecific, neuroradiologists should be aware of this condition in transplant patients treated with OKT3.