PT  - JOURNAL ARTICLE
AU  - Parizel, P M
AU  - Snoeck, H W
AU  - van den Hauwe, L
AU  - Boven, K
AU  - Bosmans, J L
AU  - Van Goethem, J W
AU  - Van Marck, E A
AU  - Cras, P
AU  - De Schepper, A M
AU  - De Broe, M E
TI  - Cerebral complications of murine monoclonal CD3 antibody (OKT3): CT and MR findings.
DP  - 1997 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1935--1938
VI  - 18
IP  - 10
4099  - http://www.ajnr.org/content/18/10/1935.short
4100  - http://www.ajnr.org/content/18/10/1935.full
SO  - Am. J. Neuroradiol.1997 Nov 01; 18
AB  - Treatment of acute renal allograft rejection with mouse monoclonal antibody (OKT3) is associated with systemic and neurologic side effects. We describe cerebral abnormalities in a 13-year-old boy with steroid-resistant renal allograft rejection. After treatment with OKT3, an acute neurologic syndrome developed, including seizures, lethargy, and decreased mental function. CT and MR imaging revealed confluent cerebral lesions at the corticomedullary junction. Contrast-enhanced MR images showed patchy enhancement, indicating blood-brain barrier dysfunction. The diagnosis of OKT3-induced encephalopathy with cerebral edema and capillary leak syndrome was made. Although CT and MR findings are nonspecific, neuroradiologists should be aware of this condition in transplant patients treated with OKT3.