PT  - JOURNAL ARTICLE
AU  - Dousset, V
AU  - Armand, J P
AU  - Lacoste, D
AU  - Mièze, S
AU  - Letenneur, L
AU  - Dartigues, J F
AU  - Caill, J M
TI  - Magnetization transfer study of HIV encephalitis and progressive multifocal leukoencephalopathy. Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.
DP  - 1997 May 01
TA  - American Journal of Neuroradiology
PG  - 895--901
VI  - 18
IP  - 5
4099  - http://www.ajnr.org/content/18/5/895.short
4100  - http://www.ajnr.org/content/18/5/895.full
SO  - Am. J. Neuroradiol.1997 May 01; 18
AB  - PURPOSE To ascertain whether the use of magnetization transfer (MT) in MR imaging can characterize tissue destruction in human immunodeficiency virus (HIV)-positive patients with presumed progressive multifocal leukoencephalopathy (PML) or HIV encephalitis.METHODS Brain MR studies that included MT were obtained in three groups: 11 healthy control subjects, 10 HIV-positive patients with clinical and radiologic findings of PML, and 13 HIV-positive patients with HIV encephalitis. MT ratios (MTRs) were calculated in PML and HIV encephalitis lesions and in normal-appearing white matter in the patients and control subjects.RESULTS PML lesions revealed a dramatic decrease in MTR (22% +/- 2.3). HIV encephalitis lesions had statistically significantly higher MTR values (40% +/- 3.8) than PML lesions. The MTR of normal-appearing white matter was significantly higher in the control subjects (47% +/- 2.3) than in the PML group (46% +/- 3.3) or the HIV encephalitis group (44% +/- 2.6).CONCLUSION MTR determinations suggest the possibility of distinguishing PML from HIV encephalitis and of indicating whether HIV encephalitis is involved in white matter that appears normal on conventional MR images.