RT Journal Article
SR Electronic
T1 Positron emission tomographic studies of aging and Alzheimer disease.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 568
OP 571
VO 4
IS 3
A1 de Leon, M J
A1 Ferris, S H
A1 George, A E
A1 Christman, D R
A1 Fowler, J S
A1 Gentes, C
A1 Reisberg, B
A1 Gee, B
A1 Emmerich, M
A1 Yonekura, Y
A1 Brodie, J
A1 Kricheff, I I
A1 Wolf, A P
YR 1983
UL http://www.ajnr.org/content/4/3/568.abstract
AB In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.