PT  - JOURNAL ARTICLE
AU  - Gado, M
AU  - Hughes, C P
AU  - Danziger, W
AU  - Chi, D
TI  - Aging, dementia, and brain atrophy: a longitudinal computed tomographic study.
DP  - 1983 May 01
TA  - American Journal of Neuroradiology
PG  - 699--702
VI  - 4
IP  - 3
4099  - http://www.ajnr.org/content/4/3/699.short
4100  - http://www.ajnr.org/content/4/3/699.full
SO  - Am. J. Neuroradiol.1983 May 01; 4
AB  - Studies involving linear measurements of ventricular size and a volumetric measurement of the cerebrospinal fluid (CSF) space were performed on elderly subjects with mild dementia of the Alzheimer type and on age-matched controls. Forty-five subjects were studied twice at a 1 year interval; linear ventricular measurements showed not only a greater degree but a more rapid evolution of brain atrophy in individuals with mild dementia as compared with controls. An additional 12 normal subjects were studied twice over a 1 year period with volumetric estimates of the CSF space, which demonstrated development of significant brain atrophy within 1 year, while linear measurements on the same scans showed no significant change. The volumetric method is regarded as a more sensitive indicator of brain volume and is potentially useful in further studies in dementia.