RT Journal Article
SR Electronic
T1 Computer-Aided Diagnosis Improves Detection of Small Intracranial Aneurysms on MRA in a Clinical Setting
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1897
OP 1902
DO 10.3174/ajnr.A3996
VO 35
IS 10
A1 Štep̌án-Buksakowska, I.L.
A1 Accurso, J.M.
A1 Diehn, F.E.
A1 Huston, J.
A1 Kaufmann, T.J.
A1 Luetmer, P.H.
A1 Wood, C.P.
A1 Yang, X.
A1 Blezek, D.J.
A1 Carter, R.
A1 Hagen, C.
A1 Hořínek, D.
A1 Hejčl, A.
A1 Roček, M.
A1 Erickson, B.J.
YR 2014
UL http://www.ajnr.org/content/35/10/1897.abstract
AB BACKGROUND AND PURPOSE: MRA is widely accepted as a noninvasive diagnostic tool for the detection of intracranial aneurysms, but detection is still a challenging task with rather low detection rates. Our aim was to examine the performance of a computer-aided diagnosis algorithm for detecting intracranial aneurysms on MRA in a clinical setting. MATERIALS AND METHODS: Aneurysm detectability was evaluated retrospectively in 48 subjects with and without computer-aided diagnosis by 6 readers using a clinical 3D viewing system. Aneurysms ranged from 1.1 to 6.0 mm (mean = 3.12 mm, median = 2.50 mm). We conducted a multireader, multicase, double-crossover design, free-response, observer-performance study on sets of images from different MRA scanners by using DSA as the reference standard. Jackknife alternative free-response operating characteristic curve analysis with the figure of merit was used. RESULTS: For all readers combined, the mean figure of merit improved from 0.655 to 0.759, indicating a change in the figure of merit attributable to computer-aided diagnosis of 0.10 (95% CI, 0.03–0.18), which was statistically significant (F1,47 = 7.00, P = .011). Five of the 6 radiologists had improved performance with computer-aided diagnosis, primarily due to increased sensitivity. CONCLUSIONS: In conditions similar to clinical practice, using computer-aided diagnosis significantly improved radiologists' detection of intracranial DSA-confirmed aneurysms of ≤6 mm. CADcomputer-aided diagnosisFOMfigure of merit