PT  - JOURNAL ARTICLE
AU  - Hodel, J.
AU  - Outteryck, O.
AU  - Ryo, E.
AU  - Bocher, A.-L.
AU  - Lambert, O.
AU  - Chéchin, D.
AU  - Zéphir, H.
AU  - Lacour, A.
AU  - Pruvo, J.-P.
AU  - Vermersch, P.
AU  - Leclerc, X.
TI  - Accuracy of Postcontrast 3D Turbo Spin-Echo MR Sequence for the Detection of Enhanced Inflammatory Lesions in Patients with Multiple Sclerosis
AID  - 10.3174/ajnr.A3795
DP  - 2014 Mar 01
TA  - American Journal of Neuroradiology
PG  - 519--523
VI  - 35
IP  - 3
4099  - http://www.ajnr.org/content/35/3/519.short
4100  - http://www.ajnr.org/content/35/3/519.full
SO  - Am. J. Neuroradiol.2014 Mar 01; 35
AB  - BACKGROUND AND PURPOSE: Therapeutic strategies for patients with MS partly rely on contrast-enhanced MR imaging. Our aim was to assess the diagnostic performance of 3D turbo spin-echo MR imaging with variable refocusing flip angles at 3T for the detection of enhanced inflammatory lesions in patients with multiple sclerosis. MATERIALS AND METHODS: Fifty-six patients with MS were prospectively investigated by using postcontrast T1-weighted axial 2D spin-echo and 3D TSE MR images. The order in which both sequences were performed was randomized. Axial reformats from 3D T1 TSE were generated to match the 2D spin-echo images. The reference standard was defined by using clinical data and all MR images available. Three separate sets of MR images (2D spin-echo images, axial reformats, and multiplanar images from 3D TSE sequences) were examined in a blinded fashion by 2 neuroradiologists separately for the detection of enhanced MS lesions. Image artifacts and contrast were evaluated. RESULTS: No artifacts related to vascular pulsation were observed on 3D TSE images, whereas image artifacts were demonstrated on 2D spin-echo images in 41 patients. One hundred twelve enhanced MS lesions were identified in 19 patients. Sixty-four lesions were correctly diagnosed by using 2D spin-echo images; 90, by using 3D TSE axial reformatted views; and 106, by using multiplanar analysis of the 3D TSE sequence. Multiplanar analysis was 94.7% sensitive and 100% specific for the diagnosis of patients with at least 1 enhanced lesion. Contrast of enhanced MS lesions was significantly improved by using the 3D TSE sequence (P < .011). CONCLUSIONS: The 3D TSE sequence with multiplanar analysis is a useful tool for the detection of enhanced MS lesions. CRcontrast rateDIRdouble inversion recoveryGREgradient recalled-echoSEspin-echo