RT Journal Article
SR Electronic
T1 Volumetric Assessment of Optic Nerve Sheath and Hypophysis in Idiopathic Intracranial Hypertension
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 513
OP 518
DO 10.3174/ajnr.A3694
VO 35
IS 3
A1 Hoffmann, J.
A1 Schmidt, C.
A1 Kunte, H.
A1 Klingebiel, R.
A1 Harms, L.
A1 Huppertz, H.-J.
A1 Lüdemann, L.
A1 Wiener, E.
YR 2014
UL http://www.ajnr.org/content/35/3/513.abstract
AB BACKGROUND AND PURPOSE: Idiopathic intracranial hypertension is a headache syndrome characterized by increased CSF pressure. Compression of the hypophysis and distension of the optic nerve sheath are reliable imaging signs. The purpose of the study was to validate, in patients with idiopathic intracranial hypertension, MR imaging–based volumetric measurements of the optic nerve sheath and hypophysis as an objective observation method for more accurate diagnosis and posttreatment follow-up. MATERIALS AND METHODS: Twenty-three patients with idiopathic intracranial hypertension as well as age-, sex-, and body mass index–matched controls underwent volumetric measurements of the optic nerve, optic nerve sheath, and hypophysis on high-resolution T2-weighted MR images by using a 7-cm surface coil, followed by correlation with CSF opening pressures and clinical symptom scores of visual disturbances and headache. RESULTS: Mean values of optic nerve sheath (341.86 ± 163.69 mm3 versus 127.56 ± 53.17 mm3, P < .001) and hypophysis volumes (554.59 ± 142.82 mm3 versus 686.60 ± 137.84 mm3, P < .05) differed significantly between healthy and diseased subjects. No significant differences between mean optic nerve volumes were observed. Receiver operating characteristic analysis showed optic nerve sheath volumes of >201.30 mm3 (sensitivity, 86.96%; specificity, 91.30%) and hypophysis volumes of <611.21 mm3 (sensitivity, 78.26%; specificity, 69.57%) to be indicative of idiopathic intracranial hypertension diagnosis. In patients with idiopathic intracranial hypertension, no correlations were found between optic nerve sheath and hypophysis volumes and CSF opening pressures or clinical scores of visual disturbances and headache. CONCLUSIONS: Semiautomated volumetric measurement of optic nerve sheath and hypophysis has the potential to more accurately diagnose and follow patients with idiopathic intracranial hypertension. cccorrelation coefficientIIHidiopathic intracranial hypertensionONoptic nerveONSoptic nerve sheath