PT  - JOURNAL ARTICLE
AU  - Sabin, N.D.
AU  - Merchant, T.E.
AU  - Harreld, J.H.
AU  - Patay, Z.
AU  - Klimo, P.
AU  - Qaddoumi, I.
AU  - Armstrong, G.T.
AU  - Wright, K.
AU  - Gray, J.
AU  - Indelicato, D.J.
AU  - Gajjar, A.
TI  - Imaging Changes in Very Young Children with Brain Tumors Treated with Proton Therapy and Chemotherapy
AID  - 10.3174/ajnr.A3219
DP  - 2013 Feb 01
TA  - American Journal of Neuroradiology
PG  - 446--450
VI  - 34
IP  - 2
4099  - http://www.ajnr.org/content/34/2/446.short
4100  - http://www.ajnr.org/content/34/2/446.full
SO  - Am. J. Neuroradiol.2013 Feb 01; 34
AB  - SUMMARY: PT promises to reduce side effects in children with brain tumors by sparing normal tissue compared with 3D conformal or intensity-modulated radiation therapy. Information is lacking about the combined effects of PT and chemotherapy in young children. We describe imaging changes in 8 very young children with localized brain tumors who received PT after chemotherapy. Mostly transient signal abnormalities and enhancement in brain parenchyma were observed by serial MR imaging, which were consistent with radiation-induced effects on normal-appearing tissue. Correlation with PT planning data revealed that the areas of imaging abnormality were located within or adjacent to the volume that received the highest radiation dose. Radiologists should be aware of these findings in children who receive PT after chemotherapy. In this report, we describe the time course of these PT-related imaging findings and correlate them with treatment and clinical outcomes. AT/RTatypical teratoid rhabdoid tumorCGEcobalt gray equivalentCPCchoroid plexus carcinomaPNETprimitive neuroectodermal tumorPTproton therapy