RT Journal Article SR Electronic T1 Light-Chain Deposition Diseases of the CNS: Review of Pathogenesis, Imaging Features, and Radiographic Mimics JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 659 OP 665 DO 10.3174/ajnr.A8390 VO 46 IS 4 A1 Rai, Pranjal A1 Soni, Neetu A1 Bathla, Girish A1 Raj, Karuna A1 Desai, Amit A1 Gupta, Vivek A1 Agarwal, Amit YR 2025 UL http://www.ajnr.org/content/46/4/659.abstract AB Light-chain deposition disease (LCDD) is a rare CNS disorder characterized by the extracellular accumulation of monoclonal immunoglobulin light chains in various organs. LCDD typically arises secondary to an underlying plasma cell dyscrasia, such as monoclonal gammopathy of undetermined significance or multiple myeloma. However, rare cases can occur in the absence of a demonstrable plasma cell disorder. The kidneys, liver, lungs, and heart are the most affected organs. Intracerebral LCDD, particularly without an underlying plasma cell neoplasm, represents an exceedingly uncommon entity with limited documented cases in the literature. This review article explores the pathogenesis, histopathologic features, and characteristic neuroimaging findings of intracerebral LCDD. We emphasize the diverse imaging presentations of this disease, which can closely resemble other neurologic pathologies. Recognizing these potential mimics is crucial for avoiding misdiagnosis, especially in the absence of a known underlying plasma cell disorder. This article aims to provide a comprehensive overview from a neuroradiologic perspective, facilitating the recognition and differentiation of this challenging entity.ALDamyloidomaIgimmunoglobulinLClight chainLCDDlight-chain deposition diseaseMIDDmonoclonal immunoglobulin deposition disease