PT  - JOURNAL ARTICLE
AU  - Rademacher, Anneliese F.
AU  - Fadel, Hassan A.
AU  - Pawloski, Jacob A.
AU  - Ma, Mia
AU  - Nkongchu, Ken N.
AU  - Lee, Ian Y.
AU  - Ali, Arafat Y.
TI  - Laser Interstitial Thermal Therapy for Intra-Axial Brain Tumors: Everything the Neuroradiologist Should Know
AID  - 10.3174/ajnr.A8427
DP  - 2025 Apr 01
TA  - American Journal of Neuroradiology
PG  - 666--674
VI  - 46
IP  - 4
4099  - http://www.ajnr.org/content/46/4/666.short
4100  - http://www.ajnr.org/content/46/4/666.full
SO  - Am. J. Neuroradiol.2025 Apr 01; 46
AB  - Laser interstitial thermal therapy (LITT) is a minimally invasive cytoreductive treatment option for patients with intracranial tumors. Utilizing real-time MR thermometry, LITT delivers tailored, targeted, and permanent cytotoxic thermal injury to intra-axial pathology. As a minimally invasive and nonionizing treatment option proved to be an effective, less morbid, and more efficient alternative to surgery, the utility of LITT has rapidly expanded. Along with this growth comes the need for neurosurgeons and neuroradiologists to accurately assess the radiographic outcomes of LITT in a standardized, dependable, and longitudinal fashion. We present a comprehensive overview of the indications and mechanisms of action of LITT for intra-axial brain tumors as well as guidance on thorough pre-, intra-, and postoperative imaging assessments. Using detailed case examples describing the contemporary uses of LITT, we hope to provide a foundational understanding of LITT that will inform imaging assessment and guide accurate multi disciplinary tumor board discussion.CEMcumulative equivalent minutesLITTlaser interstitial thermal therapyPRFproton resonance frequencySPGRspoiled gradient recalled echoWHOWorld Health Organization