PT  - JOURNAL ARTICLE
AU  - Hoffmann, Angelika
AU  - Almiri, Willian
AU  - Mordasini, Pasquale
AU  - Bähler, Alexandrine
AU  - Seiffge, David J.
AU  - Göldlin, Martina B.
AU  - Jäger, Eugen
AU  - Muresan, Ioan-Paul
AU  - Christ, Lisa
AU  - Heldner, Mirjam R.
AU  - Wiest, Roland
AU  - Radojewski, Piotr
TI  - 7T MRI as a powerful tool to detect small and medium size vessel CNS vasculitis
AID  - 10.3174/ajnr.A8627
DP  - 2024 Dec 17
TA  - American Journal of Neuroradiology
PG  - ajnr.A8627
4099  - http://www.ajnr.org/content/early/2024/12/17/ajnr.A8627.short
4100  - http://www.ajnr.org/content/early/2024/12/17/ajnr.A8627.full
AB  - Imaging can help to diagnose CNS vasculitis. Yet so far, no imaging studies of CNS vasculitis at 7T are available. We share our experience of vessel wall imaging (VWI) at 7T in patients with suspected vasculitis. All included patients (n=45) underwent a clinically approved 7T MRI comprising high resolution arterial TOF angiography as well as high resolution VWI with T1SPACE and T1SE acquired pre-and post-contrast. 23 patients showed negative and 22 patients positive VWI at 7T. Ten out of 22 7T VWI positive cases were suggestive of vasculitis with 9 patients showing VWI of large and medium size vessels and one patient VWI of small vessels. Small vessel vasculitis was only depicted with 7T VWI, but not 3T VWI. Our work demonstrates that diagnosing CNS vasculitis, especially small vessel vasculitis, is feasible at 7T and highlights the potential of high field VWI encouraging further studies in this field.ABBREVIATIONS: FS= fat-saturated, SNR= signal-to-noise ratio, VWI= vessel wall imaging