RT Journal Article
SR Electronic
T1 A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1846
OP 1856
DO 10.3174/ajnr.A8396
VO 45
IS 12
A1 Ellingson, Benjamin M.
A1 Sanvito, Francesco
A1 Cloughesy, Timothy F.
A1 Huang, Raymond Y.
A1 Villanueva-Meyer, Javier E.
A1 Pope, Whitney B.
A1 Barboriak, Daniel P.
A1 Shankar, Lalitha K.
A1 Smits, Marion
A1 Kaufmann, Timothy J.
A1 Boxerman, Jerrold L.
A1 Weller, Michael
A1 Galanis, Evanthia
A1 Groot, John de
A1 Gilbert, Mark R.
A1 Lassman, Andrew B.
A1 Shiroishi, Mark S.
A1 Nabavizadeh, Ali
A1 Mehta, Minesh
A1 Stupp, Roger
A1 Wick, Wolfgang
A1 Reardon, David A.
A1 Vogelbaum, Michael A.
A1 van den Bent, Martin
A1 Chang, Susan M.
A1 Wen, Patrick Y.
YR 2024
UL http://www.ajnr.org/content/45/12/1846.abstract
AB SUMMARY: Radiographic assessment plays a crucial role in the management of patients with central nervous system (CNS) tumors, aiding in treatment planning and evaluation of therapeutic efficacy by quantifying response. Recently, an updated version of the Response Assessment in Neuro-Oncology (RANO) criteria (RANO 2.0) was developed to improve upon prior criteria and provide an updated, standardized framework for assessing treatment response in clinical trials for gliomas in adults. This article provides an overview of significant updates to the criteria including (1) the use of a unified set of criteria for high and low grade gliomas in adults; (2) the use of the post-radiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas; (3) the option for the trial to mandate a confirmation scan to more reliably distinguish pseudoprogression from tumor progression; (4) the option of using volumetric tumor measurements; and (5) the removal of subjective non-enhancing tumor evaluations in predominantly enhancing gliomas (except for specific therapeutic modalities). Step-by-step pragmatic guidance is hereby provided for the neuroradiologist and imaging core lab involved in operationalization and technical execution of RANO 2.0 in clinical trials, including the display of representative cases and in-depth discussion of challenging scenarios.BTIPBrain Tumor Imaging ProtocolCEContrast-EnhancingCNSCentral Nervous SystemCRComplete ResponseECOGEastern Cooperative Oncology GroupHGGHigh-Grade GliomaIDHIsocitrate DehydrogenaseIRFIndependent Radiologic FacilityKPSKarnofsky Performance StatusLGGLow-Grade GliomaMRMinor ResponsemRANOModified RANONANONeurological Assessment in Neuro-OncologyORRObjective Response RateOSOverall SurvivalPDProgressive DiseasePFSProgression-Free SurvivalPRPartial ResponsePsPPseudoprogressionRANOResponse Assessment in Neuro-OncologyRECISTResponse Evaluation Criteria In Solid TumorsRTRadiation TherapySDStable DiseaseTxTreatment