PT  - JOURNAL ARTICLE
AU  - Mastorakos, Panagiotis
AU  - Naamani, Kareem El
AU  - Adeeb, Nimer
AU  - Lan, Mathews
AU  - Castiglione, James
AU  - Khanna, Omaditya
AU  - Ghosh, Ritam
AU  - Bengzon Diestro, Jose Danilo
AU  - Dibas, Mahmoud
AU  - McLellan, Rachel M.
AU  - Algin, Oktay
AU  - Ghozy, Sherief
AU  - Cancelliere, Nicole M.
AU  - Aslan, Assala
AU  - Cuellar-Saenz, Hugo H.
AU  - Lay, Sovann V.
AU  - Guenego, Adrien
AU  - Renieri, Leonardo
AU  - Carnevale, Joseph
AU  - Saliou, Guillaume
AU  - Shotar, Eimad
AU  - Premat, Kevin
AU  - Möhlenbruch, Markus
AU  - Kral, Michael
AU  - Vranic, Justin E.
AU  - Chung, Charlotte
AU  - Salem, Mohamed M.
AU  - Lylyk, Ivan
AU  - Foreman, Paul M.
AU  - Vachhani, Jay A.
AU  - Shaikh, Hamza
AU  - Župančić, Vedran
AU  - Hafeez, Muhammad U.
AU  - Catapano, Joshua
AU  - Waqas, Muhammad
AU  - Tutino, Vincent M.
AU  - Ibrahim, Mohamed K.
AU  - Mohammed, Marwa A.
AU  - Rabinov, James D.
AU  - Ren, Yifan
AU  - Schirmer, Clemens M.
AU  - Piano, Mariangela
AU  - Bullrich, Maria Bres
AU  - Mayich, Michael
AU  - Kühn, Anna L.
AU  - Michelozzi, Caterina
AU  - Elens, Stéphanie
AU  - Starke, Robert M.
AU  - Hassan, Ameer E.
AU  - Ogilvie, Mark
AU  - Nguyen, Anh
AU  - Jones, Jesse
AU  - Brinjikji, Waleed
AU  - Psychogios, Marios
AU  - Ulfert, Christian
AU  - Spears, Julian
AU  - Jankowitz, Brian T.
AU  - Burkhardt, Jan-Karl
AU  - Domingo, Ricardo A.
AU  - Huynh, Thien
AU  - Tawk, Rabih G.
AU  - Lubicz, Boris
AU  - Nawka, Marie T.
AU  - Panni, Pietro
AU  - Puri, Ajit S.
AU  - Pero, Guglielmo
AU  - Nossek, Erez
AU  - Raz, Eytan
AU  - Killer-Oberpfalzer, Monika
AU  - Ozates, M. Ozgur
AU  - Ayberk, Giyas
AU  - Regenhardt, Robert W.
AU  - Griessenauer, Christoph J.
AU  - Asadi, Hamed
AU  - Siddiqui, Adnan
AU  - Ducruet, Andrew F.
AU  - Albuquerque, Felipe C.
AU  - Patel, Nirav J.
AU  - Stapleton, Christopher J.
AU  - Kan, Peter
AU  - Kalousek, Vladimir
AU  - Lylyk, Pedro
AU  - Boddu, Srikanth
AU  - Knopman, Jared
AU  - Aziz-Sultan, Mohammad A.
AU  - Clarençon, Frédéric
AU  - Limbucci, Nicola
AU  - Zanaty, Mario
AU  - Martinez-Gutierrez, Juan Carlos
AU  - Sheth, Sunil
AU  - Spiegel, Gary
AU  - Abbas, Rawad
AU  - Amllay, Abdelaziz
AU  - Tjoumakaris, Stavropoula I.
AU  - Gooch, Michael R.
AU  - Herial, Nabeel A.
AU  - Rosenwasser, Robert H.
AU  - Zarzour, Hekmat
AU  - Schmidt, Richard F.
AU  - Pereira, Vitor Mendes
AU  - Patel, Aman B.
AU  - Jabbour, Pascal M.
AU  - Dmytriw, Adam A.
TI  - Predictors of Aneurysm Obliteration in Patients Treated with the WEB Device: Results of a Multicenter Retrospective Study
AID  - 10.3174/ajnr.A8324
DP  - 2024 Jul 01
TA  - American Journal of Neuroradiology
PG  - 906--911
VI  - 45
IP  - 7
4099  - http://www.ajnr.org/content/45/7/906.short
4100  - http://www.ajnr.org/content/45/7/906.full
SO  - Am. J. Neuroradiol.2024 Jul 01; 45
AB  - BACKGROUND AND PURPOSE: Despite the numerous studies evaluating the occlusion rates of aneurysms following WEB embolization, there are limited studies identifying predictors of occlusion. Our purpose was to identify predictors of aneurysm occlusion and the need for retreatment.MATERIALS AND METHODS: This is a review of a prospectively maintained database across 30 academic institutions. We included patients with previously untreated cerebral aneurysms embolized using the WEB who had available intraprocedural data and long-term follow-up.RESULTS: We studied 763 patients with a mean age of 59.9 (SD, 11.7) years. Complete aneurysm occlusion was observed in 212/726 (29.2%) cases, and contrast stasis was observed in 485/537 (90.3%) of nonoccluded aneurysms. At the final follow-up, complete occlusion was achieved in 497/763 (65.1%) patients, and retreatment was required for 56/763 (7.3%) patients. On multivariable analysis, history of smoking, maximal aneurysm diameter, and the presence of an aneurysm wall branch were negative predictors of complete occlusion (OR, 0.5, 0.8, and 0.4, respectively). Maximal aneurysm diameter, the presence of an aneurysm wall branch, posterior circulation location, and male sex increase the chances of retreatment (OR, 1.2, 3.8, 3.0, and 2.3 respectively). Intraprocedural occlusion resulted in a 3-fold increase in the long-term occlusion rate and a 5-fold decrease in the retreatment rate (P < .001), offering a specificity of 87% and a positive predictive value of 85% for long-term occlusion.CONCLUSIONS: Intraprocedural occlusion can be used to predict the chance of long-term aneurysm occlusion and the need for retreatment after embolization with a WEB device. Smoking, aneurysm size, and the presence of an aneurysm wall branch are associated with decreased chances of successful treatment.ROCreceiver operating characteristic