PT  - JOURNAL ARTICLE
AU  - Takanashi, Jun-ichi
AU  - Barkovich, A. James
AU  - Clegg, Nancy J.
AU  - Delgado, Mauricio R.
TI  - Middle Interhemispheric Variant of Holoprosencephaly Associated with Diffuse Polymicrogyria
DP  - 2003 Mar 01
TA  - American Journal of Neuroradiology
PG  - 394--397
VI  - 24
IP  - 3
4099  - http://www.ajnr.org/content/24/3/394.short
4100  - http://www.ajnr.org/content/24/3/394.full
SO  - Am. J. Neuroradiol.2003 Mar 01; 24
AB  - Summary: An 11-month-old boy was discovered to have a cleft palate, club foot, hypospadias, and myoclonic seizures. No in utero exposure to teratogens was identified. Brain MR imaging revealed a middle interhemispheric fusion variant of holoprosencephaly, diffuse polymicrogyria, and a hypoplastic brain stem; this was a distinctly unusual association of findings. We hypothesize that an unknown genetic factor causes disturbances of cleavage of the prosencephalon as well as neuronal migration and organization.