PT - JOURNAL ARTICLE AU - Li, Ting AU - Chen, Xin AU - Jing, Yang AU - Wang, Haoru AU - Zhang, Ting AU - Zhang, Li AU - Ding, Hao AU - Xie, Mingye AU - He, Ling TI - Diagnostic Value of Multiparameter MRI-Based Radiomics in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorders AID - 10.3174/ajnr.A8045 DP - 2023 Dec 01 TA - American Journal of Neuroradiology PG - 1425--1431 VI - 44 IP - 12 4099 - http://www.ajnr.org/content/44/12/1425.short 4100 - http://www.ajnr.org/content/44/12/1425.full SO - Am. J. Neuroradiol.2023 Dec 01; 44 AB - BACKGROUND AND PURPOSE: Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) have a higher prevalence among children. For children undergoing the initial manifestation of MOGAD, prompt diagnosis has paramount importance. This study assessed the performance of multiparameter MRI-based radiomics in distinguishing patients with and without MOGAD with idiopathic inflammatory demyelinating diseases.MATERIALS AND METHODS: We enrolled a cohort of 121 patients diagnosed with idiopathic inflammatory demyelinating diseases, including 68 children with MOGAD and 53 children without MOGAD. Radiomics models (T1WI, T2WI, FLAIR, and compound model) using features extracted from demyelinating lesions within the brain parenchyma were developed in the training set. The performance of these models underwent validation within the internal testing set. Additionally, we gathered clinical factors and MRI features of brain parenchymal lesions at their initial presentation. Subsequently, these variables were used in the construction of a clinical prediction model through multivariate logistic regression analysis.RESULTS: The areas under the curve for the radiomics models (T1WI, T2WI, FLAIR, and the compound model) in the training set were 0.781 (95% CI, 0.689–0.864), 0.959 (95% CI, 0.924–0.987), 0.939 (95% CI, 0.898–0.979), and 0.989 (95% CI, 0.976–0.999), respectively. The areas under the curve for the radiomics models (T1WI, T2WI, FLAIR, and the compound model) in the testing set were 0.500 (95% CI, 0.304–0.652), 0.833 (95% CI, 0.697–0.944), 0.804 (95% CI, 0.664–0.918), and 0.905 (95% CI, 0.803–0.979), respectively. The areas under the curve of the clinical prediction model in the training set and testing set were 0.700 and 0.289, respectively.CONCLUSIONS: Multiparameter MRI-based radiomics helps distinguish MOGAD from non-MOGAD in patients with idiopathic inflammatory demyelinating diseases.AUCarea under the ROC curveIIDDsidiopathic inflammatory demyelinating diseasesLASSOleast absolute shrinkage and selection operatorMOGmyelin oligodendrocyte glycoproteinMOGADmyelin oligodendrocyte glycoprotein antibody associated disordersNMOSDneuromyelitis optica spectrum disorderROCreceiver operating characteristic