RT Journal Article
SR Electronic
T1 Discrepant MR Spectroscopic and Perfusion Imaging Results in a Case of Malignant Transformation of Cerebral Glioma
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1775
OP 1778
VO 23
IS 10
A1 Wu, Wen-Chau
A1 Chen, Cheng-Yu
A1 Chung, Hsiao-Wen
A1 Juan, Chun-Jung
A1 Hsueh, Chun-Jen
A1 Gao, Hong-Wei
YR 2002
UL http://www.ajnr.org/content/23/10/1775.abstract
AB Summary: We present serial MR perfusion and spectroscopic findings of a pathologically proved low grade glioma, which evolved into glioblastoma multiforme in 2 years in a 24-year-old man. The initial MR imaging studies, including enhanced conventional T1-weighted and perfusion imaging, were characteristic of a benign glioma with the only exception being that multi-voxel proton MR spectroscopy showed malignant features with a high choline:phosphocreatine ratio. Postoperative follow-up MR imaging revealed findings consistent with malignant glioma, with increased angiogenesis on perfusion images and heterogeneous enhancement on contrast-enhanced T1-weighted images that were further confirmed by second surgery. We suggest conducting close MR imaging follow-up of patients with glioma who have discrepant MR spectroscopic and perfusion results after treatment.