PT  - JOURNAL ARTICLE
AU  - Legrand, L.
AU  - Le Berre, A.
AU  - Seners, P.
AU  - Benzakoun, J.
AU  - Ben Hassen, W.
AU  - Lion, S.
AU  - Boulouis, G.
AU  - Cottier, J.-P.
AU  - Costalat, V.
AU  - Bracard, S.
AU  - Berthezene, Y.
AU  - Ozsancak, C.
AU  - Provost, C.
AU  - Naggara, O.
AU  - Baron, J.-C.
AU  - Turc, G.
AU  - Oppenheim, C.
TI  - FLAIR Vascular Hyperintensities as a Surrogate of Collaterals in Acute Stroke: DWI Matters
AID  - 10.3174/ajnr.A7733
DP  - 2022 Dec 15
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2022/12/15/ajnr.A7733.short
4100  - http://www.ajnr.org/content/early/2022/12/15/ajnr.A7733.full
AB  - BACKGROUND AND PURPOSE: FLAIR vascular hyperintensities are thought to represent leptomeningeal collaterals in acute ischemic stroke. However, whether all–FLAIR vascular hyperintensities or FLAIR vascular hyperintensities–DWI mismatch, ie, FLAIR vascular hyperintensities beyond the DWI lesion, best reflects collaterals remains debated. We aimed to compare the value of FLAIR vascular hyperintensities–DWI mismatch versus all–FLAIR vascular hyperintensities for collateral assessment using PWI-derived collateral flow maps as a reference.MATERIALS AND METHODS: We retrospectively reviewed the registries of 6 large stroke centers and included all patients with acute stroke with anterior circulation large-vessel occlusion who underwent MR imaging with PWI before thrombectomy. Collateral status was graded from 1 to 4 on PWI-derived collateral flow maps and dichotomized into good (grades 3–4) and poor (grades 1–2). The extent of all–FLAIR vascular hyperintensities and FLAIR vascular hyperintensities–DWI mismatch was assessed on the 7 cortical ASPECTS regions, ranging from 0 (absence) to 7 (extensive), and associations with good collaterals were compared using receiver operating characteristic curves.RESULTS: Of the 209 included patients, 133 (64%) and 76 (36%) had good and poor collaterals, respectively. All–FLAIR vascular hyperintensity extent was similar between collateral groups (P = .76). Conversely, FLAIR vascular hyperintensities–DWI mismatch extent was significantly higher in patients with good compared with poor collaterals (P < .001). The area under the curve was 0.80 (95% CI, 0.74–0.87) for FLAIR vascular hyperintensities–DWI mismatch and 0.52 (95% CI, 0.44–0.60) for all–FLAIR vascular hyperintensities (P < .001 for the comparison), to predict good collaterals. Variables independently associated with good collaterals were smaller DWI lesion volume (P < .001) and larger FLAIR vascular hyperintensities–DWI mismatch (P = .02).CONCLUSIONS: In acute ischemic stroke with large-vessel occlusion, the extent of FLAIR vascular hyperintensities does not reliably reflect collateral status unless one accounts for DWI.AISacute ischemic strokeASITN/SIRAmerican Society of Interventional and Therapeutic Neuroradiology/Society of Interventional RadiologyFVHFLAIR vascular hyperintensitiesHIRhypoperfusion intensity ratioIQRinterquartile rangeIVTIV thrombolysisLVOlarge-vessel occlusionMTmechanical thrombectomyROCreceiver operating characteristicTmaxtime-to-maximum