PT  - JOURNAL ARTICLE
AU  - Majoie, Charles B.
AU  - Akkerman, Erik M.
AU  - Blank, Christian
AU  - Barth, Peter G.
AU  - Poll-The, Bwee Tien
AU  - den Heeten, G.J.
TI  - Mitochondrial Encephalomyopathy: Comparison of Conventional MR Imaging with Diffusion-Weighted and Diffusion Tensor Imaging: Case Report
DP  - 2002 May 01
TA  - American Journal of Neuroradiology
PG  - 813--816
VI  - 23
IP  - 5
4099  - http://www.ajnr.org/content/23/5/813.short
4100  - http://www.ajnr.org/content/23/5/813.full
SO  - Am. J. Neuroradiol.2002 May 01; 23
AB  - Summary: Conventional MR imaging, MR spectroscopy, diffusion-weighted imaging, and diffusion tensor imaging were performed in a 5-month-old male patient with mitochondrial encephalomyopathy. On conventional T2-weighted MR images, symmetric, confluent high signal intensity was found in the temporoparietal white matter. A large lactate peak and decreased N-acetylaspartate were found in this region on proton MR spectroscopic images. Diffusion-weighted imaging showed increased apparent diffusion coefficient, representing vasogenic edema. Diffusion tensor imaging revealed decreased anisotropy, consistent with injury to the oligodendro-axonal unit. A muscle biopsy specimen revealed an isolated complex III enzyme respiratory chain deficiency. Diffusion-weighted and diffusion tensor imaging are valuable techniques for the characterization of hyperintense lesions on T2-weighted MR images in cases of mitochondrial encephalomyopathy.