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<article xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="1.3" article-type="research-article" xml:lang="en"><processing-meta tagset-family="jats" base-tagset="archiving" mathml-version="3.0" table-model="xhtml"><custom-meta-group><custom-meta assigning-authority="highwire" xlink:type="simple"><meta-name>recast-jats-build</meta-name><meta-value>d8e1462159</meta-value></custom-meta></custom-meta-group></processing-meta><front><journal-meta><journal-id journal-id-type="hwp">jitc</journal-id><journal-id journal-id-type="nlm-ta">J Immunother Cancer</journal-id><journal-id journal-id-type="publisher-id">40425</journal-id><journal-title-group><journal-title>Journal for ImmunoTherapy of Cancer</journal-title><abbrev-journal-title abbrev-type="publisher">J Immunother Cancer</abbrev-journal-title></journal-title-group><issn pub-type="epub">2051-1426</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">s40425-019-0830-7</article-id><article-id pub-id-type="manuscript">830</article-id><article-id pub-id-type="doi">10.1186/s40425-019-0830-7</article-id><article-id pub-id-type="pmid">31843014</article-id><article-id pub-id-type="apath" assigning-authority="highwire">/jitc/7/1/349.atom</article-id><article-categories><subj-group subj-group-type="heading"><subject>Correction</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Correction to: Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Metzger</surname><given-names>Philipp</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kirchleitner</surname><given-names>Sabrina V.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kluge</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Koenig</surname><given-names>Lars M.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Hörth</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Rambuscheck</surname><given-names>Carlotta A.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Böhmer</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ahlfeld</surname><given-names>Julia</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kobold</surname><given-names>Sebastian</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Friedel</surname><given-names>Caroline C.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Endres</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Schnurr</surname><given-names>Max</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes" xlink:type="simple"><name name-style="western"><surname>Duewell</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="corresp" rid="IDs4042501908307_cor13">m</xref></contrib><aff id="Aff1">
<label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0477 2585</institution-id><institution-id institution-id-type="GRID">grid.411095.8</institution-id><institution content-type="org-division" xlink:type="simple">Center of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology</institution><institution content-type="org-name" xlink:type="simple">Klinikum der Universität München</institution></institution-wrap>
<addr-line content-type="street">Lindwurmstrasse 2a</addr-line>
<addr-line content-type="postcode">80337</addr-line>
<addr-line content-type="city">Munich</addr-line>
<country country="DE">Germany</country>
</aff><aff id="Aff2">
<label>2</label>
<institution-wrap><institution content-type="org-division" xlink:type="simple">Department of Neurosurgery</institution><institution content-type="org-name" xlink:type="simple">University Hospital, LMU Munich</institution></institution-wrap>
<addr-line content-type="postcode">81377</addr-line>
<addr-line content-type="city">Munich</addr-line>
<country country="DE">Germany</country>
</aff><aff id="Aff3">
<label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 973X</institution-id><institution-id institution-id-type="GRID">grid.5252.0</institution-id><institution content-type="org-name" xlink:type="simple">Institute for Informatics, Ludwig-Maximilians-Universität München</institution></institution-wrap>
<addr-line content-type="postcode">80333</addr-line>
<addr-line content-type="city">Munich</addr-line>
<country country="DE">Germany</country>
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<label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2240 3300</institution-id><institution-id institution-id-type="GRID">grid.10388.32</institution-id><institution content-type="org-name" xlink:type="simple">Institute of Innate Immunity, University of Bonn</institution></institution-wrap>
<addr-line content-type="street">Venusberg-Campus 1</addr-line>
<addr-line content-type="postcode">53127</addr-line>
<addr-line content-type="city">Bonn</addr-line>
<country country="DE">Germany</country>
</aff></contrib-group><author-notes><corresp id="IDs4042501908307_cor13">
<label>m</label>
<email xlink:type="simple">pduewell@uni-bonn.de</email>
</corresp><fn fn-type="other"><p>The original version of this article was revised: the authors have reported that Figure 2 and S2 partially show red scripts.</p></fn></author-notes><pub-date date-type="pub" iso-8601-date="2019-12" pub-type="ppub" publication-format="print"><month>12</month><year>2019</year></pub-date><pub-date date-type="pub" iso-8601-date="2019-12-16" pub-type="epub-original" publication-format="electronic"><day>16</day><month>12</month><year>2019</year></pub-date><pub-date iso-8601-date="2019-11-18T10:22:57-08:00" pub-type="hwp-received"><day>18</day><month>11</month><year>2019</year></pub-date><pub-date iso-8601-date="2019-11-18T10:22:57-08:00" pub-type="hwp-created"><day>18</day><month>11</month><year>2019</year></pub-date><pub-date iso-8601-date="2019-12-16T00:00:00-08:00" pub-type="epub"><day>16</day><month>12</month><year>2019</year></pub-date><volume>7</volume><issue>1</issue><elocation-id>349</elocation-id><permissions><copyright-statement>© The Author(s).</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/" xlink:type="simple"><license-p>
<bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/" xlink:type="simple">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="40425_2019_Article_830_nlm.pdf" xlink:type="simple"/><related-article related-article-type="corrected-article" ext-link-type="doi" xlink:href="10.1186/s40425-019-0778-7" xlink:type="simple"/><abstract id="Abs1" xml:lang="en"><p>Following publication of the original article [1], the authors have reported that Fig. 2 and Additional file 1: Figure S1, S2 partially show red scripts.</p></abstract><custom-meta-group><custom-meta xlink:type="simple"><meta-name>publisher-imprint-name</meta-name><meta-value>BioMed Central</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>volume-issue-count</meta-name><meta-value>2</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>issue-article-count</meta-name><meta-value>0</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>issue-toc-levels</meta-name><meta-value>0</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>issue-pricelist-year</meta-name><meta-value>2019</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>issue-copyright-holder</meta-name><meta-value>The Author(s)</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>issue-copyright-year</meta-name><meta-value>2019</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-contains-esm</meta-name><meta-value>Yes</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-numbering-style</meta-name><meta-value>Unnumbered</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-registration-date-year</meta-name><meta-value>2019</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-registration-date-month</meta-name><meta-value>11</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-registration-date-day</meta-name><meta-value>29</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-toc-levels</meta-name><meta-value>0</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>toc-levels</meta-name><meta-value>0</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>volume-type</meta-name><meta-value>Regular</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>journal-product</meta-name><meta-value>ArchiveJournal</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>numbering-style</meta-name><meta-value>Unnumbered</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-grants-type</meta-name><meta-value>OpenChoice</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>metadata-grant</meta-name><meta-value>OpenAccess</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>abstract-grant</meta-name><meta-value>OpenAccess</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>bodypdf-grant</meta-name><meta-value>OpenAccess</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>bodyhtml-grant</meta-name><meta-value>OpenAccess</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>bibliography-grant</meta-name><meta-value>OpenAccess</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>esm-grant</meta-name><meta-value>OpenAccess</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>online-first</meta-name><meta-value>false</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>pdf-file-reference</meta-name><meta-value>BodyRef/PDF/40425_2019_Article_830.pdf</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>pdf-type</meta-name><meta-value>Typeset</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>target-type</meta-name><meta-value>OnlinePDF</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>issue-type</meta-name><meta-value>Regular</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>article-type</meta-name><meta-value>Erratum</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>journal-subject-primary</meta-name><meta-value>Medicine &amp; Public Health</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>journal-subject-secondary</meta-name><meta-value>Oncology</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>journal-subject-secondary</meta-name><meta-value>Immunology</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>journal-subject-collection</meta-name><meta-value>Medicine</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>open-access</meta-name><meta-value>true</meta-value></custom-meta><custom-meta xlink:type="simple"><meta-name>special-property</meta-name><meta-value>contains-inline-supplementary-material</meta-value></custom-meta></custom-meta-group></article-meta><notes notes-type="AuthorContribution"><p>Philipp Metzger and Sabrina V. Kirchleitner contributed equally to this work.</p><p>Max Schnurr and Peter Duewell contributed equally to this work.</p><p>The original article can be found online at 10.1186/s40425-019-0778-7</p></notes></front><body><p id="Par2">
<bold>Correction to: J ImmunoTher Cancer (2019) 7:288</bold>
</p><p id="Par3">
<bold>https://doi.org/10.1186/s40425-019-0778-7</bold>
</p><p id="Par4">Following publication of the original article [<xref ref-type="bibr" rid="CR1">1</xref>], the authors have reported that Fig. <xref rid="Fig1" ref-type="fig">2</xref> and Additional file <xref rid="MOESM1" ref-type="supplementary-material">1</xref>: Figure S1, S2 partially show red scripts.<fig id="Fig1" position="float" orientation="portrait"><object-id pub-id-type="publisher-id">Fig1</object-id><label>Fig. 2</label><caption xml:lang="en"><p>Poly(I:C)<sub>c</sub> reduces tumor mass in PDAC concomitant with enhanced T cell activation and reduced suppressive capacity of MDSC. Mice with orthotopic T110299 tumors were treated with poly(I:C)<sub>c</sub> twice prior to sacrifice at day 21 after tumor induction. <bold>a</bold> Tumor weights, tumor cell MHC-I expression and (<bold>b</bold>) serum cytokine levels. <bold>c</bold> Frequencies of MDSC populations in spleen and tumor of untreated and poly(I:C)<sub>c</sub>-treated mice. <bold>d</bold> Surface expression profiles of PD-L1 on MDSC subsets. <bold>e</bold> Frequencies of T cell populations in spleen and tumor of untreated and poly(I:C)<sub>c</sub>-treated mice. <bold>f-g</bold> CD69 and PD-1 surface expression of splenic and tumor-resident T cells. <bold>h</bold> Representative data of IFN-γ secretion in MDSC / T cell co-cultures, at a ratio of 1:1, following anti-CD3/anti-CD28 mAb-coated beads stimulation for 72 h. <bold>i</bold> Splenic T cells and MDSC from spleens and tumors of untreated or poly(I:C)<sub>c</sub>-treated tumor-bearing mice were isolated and co-cultured with CFSE-labeled T cells in increasing effector (E; MDSC) to target (T; T cell) ratios (E:T) of 0.25:1, 0.5:1 and 1:1 in the presence of anti-CD3/anti-CD28 mAb-coated beads. After 72 h CFSE dilution of CD4<sup>+</sup> and CD8<sup>+</sup> T cells was assessed. <bold>a-f</bold> Data ± SEM is shown for <italic toggle="yes">n</italic> = 5 to 8 mice per group. <bold>g</bold>-<bold>h</bold> Representative graph of three independent experiments. Data± SEM for <italic toggle="yes">n</italic> = 2 mice per group,unpaired two-sided students t test (*<italic toggle="yes">p</italic> &lt; 0.05; **<italic toggle="yes">p</italic> &lt; 0.01)</p></caption><graphic specific-use="JPEG" mime-subtype="PNG" xlink:href="40425_2019_830_Fig1_HTML.jpg" position="float" orientation="portrait" xlink:type="simple"/></fig>
</p><p id="Par5">In Fig. <xref rid="Fig1" ref-type="fig">2</xref>:<list list-type="bullet"><list-item><p id="Par6">A: Red font “MHC-I (MFI x 10<sup>3</sup>)” should change to black font;</p></list-item><list-item><p id="Par7">C: Red font “<underline>0.07</underline>” and “M-MDSC” should change to black font.</p></list-item></list>
</p><p id="Par8">In Additional file <xref rid="MOESM1" ref-type="fig">1</xref>: Figure S1, S2:<list list-type="bullet"><list-item><p id="Par9">S1: Red font “Spleen” and “Tumor” should change to black font;</p></list-item><list-item><p id="Par10">S2: Red font “C”, “D”, “E”, “F”, “G”, “H” should change to black font.</p></list-item></list>
</p><p id="Par11">The correct version of the figures can be found below.</p><p id="Par12">The corrections have been implemented in the original article as well.</p><p id="Par13">We apologize for the inconvenience.</p></body><back><fn-group><fn fn-type="other"><label>Supplementary information</label><p>
<bold>Supplementary information</bold> accompanies this paper at 10.1186/s40425-019-0830-7.</p></fn></fn-group><ref-list id="Bib1"><title>Reference</title><ref id="CR1"><label>1.</label><mixed-citation publication-type="journal" xlink:type="simple">
<person-group person-group-type="author">
<string-name name-style="western">
<surname>Metzger</surname>
</string-name>, <etal>et al</etal>
</person-group>. <source>J ImmunoTher Cancer</source>. <year>2019</year>;<volume>7</volume>:<fpage>288</fpage>
<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1186/s40425-019-0778-7" xlink:type="simple">doi:10.1186/s40425-019-0778-7</ext-link>
<pub-id pub-id-type="pmcid" xlink:type="simple">6836385</pub-id> </mixed-citation></ref></ref-list><app-group><app id="App1"><title>Supplementary information</title><p id="Par14">
<supplementary-material content-type="local-data" id="MOESM1" xlink:title="Supplementary information" position="float" orientation="portrait" xlink:type="simple"><object-id pub-id-type="publisher-id">MOESM1</object-id><media xlink:href="40425_2019_830_MOESM1_ESM.pdf" mimetype="application" mime-subtype="pdf" position="float" orientation="portrait" xlink:type="simple"><caption xml:lang="en"><p>Additional file 1: Figure S1.. Gating strategy for the identification of MDSC populations. <bold>Figure S2.</bold> Poly(I:C)c reduces macrophage frequency and activates macrophages, cDC, B and NK cells. <bold>Figure S3.</bold> Poly(I:C)c triggers transcriptional reprogramming of MDSC. <bold>Figure S4.</bold> Significantly regulated genes in PMN- and M-MDSC upon poly(I:C)c therapy.</p></caption></media></supplementary-material>
</p></app></app-group></back></article>