Article Figures & Data
Figures
- FIG 1.
Patient ascertainment algorithm.
- FIG 2.
Axial spinal cord columns. A, Axial T2 spinal cord imaging. B, Superimposed schematic of axial columns on axial MR image. C, Schematic diagram of axial columns of spinal cord.
- FIG 3.
Examples of critical T2-hyperintense demyelinating lesions on sagittal T2-weighted images. Imaging composite of sagittal T2-weighted images in patients with critical lesions with corresponding axial images. A right C1 T2-hyperintense lesion with focal atrophy (A, arrow). A left C4 T2-hyperintense lesion with focal atrophy (B, arrow). A right-sided upper thoracic spine; T2-hyperintense lesion with focal atrophy (C, arrow). A left-sided C4-C5 T2-hyperintense lesion with focal atrophy (D1, arrow). An additional noncritical lesion is noted at the C6 level (D2, arrow).
- FIG 4.
Examples of critical T2-hyperintense demyelinating lesions on axial T2-weighted images. Imaging composite of axial T2-weighted images in patients with critical lesions, corresponding to sagittal images and clinical details. The corresponding axial images reveal a T2-hyperintense lesion in the right lateral column with focal atrophy (A, arrow), a T2-hyperintense lesion in the left lateral column with focal atrophy (B, arrow), a T2-hyperintense lesion in the right lateral column with focal atrophy (C, arrow), a T2-hyperintense lesion in the left lateral column with focal atrophy (D1, arrow), and a T2-hyperintense lesion in the right lateral column without focal atrophy (D2, arrow).
Tables
Clinical Characteristics Demographics Female sex (No.) (%) 51 (56%) White ethnicity (No.) (%) 88 (97%) Median age at first symptom (range) (yr) 50 (28–65) Median age at last MR imaging (range) (yr) 58 (36–80) Median age at progression (range) (yr) 52 (30–73) Clinical course (No.) (%) Progression from onset (primary-progressive) 56/91 (62%) Relapse onset (secondary-progressive) 25/91 (28%) Clinical cohort (No.) (%) PUHMS 37 (41%) PPS 35 (38%) PSS 19 (21%) - Table 2:
MR imaging characteristics in 91 critical and 88 noncritical spinal cord demyelinating lesions
Critical Spinal Cord Demyelinating Lesion (n = 91) Noncritical Spinal Cord Demyelinating Lesion (n = 88) OR 95% CI P Value Sagittal location (No.) (%) Cervical 74 (81) 63 (64) Thoracic 17 (19) 25 (26) Moderate/severe atrophy (No.) (%) 41 (45) 0 (0%) 161.91 (9.43 to >999.9) .0005 Axial column location (No.) (%) Lateral 86 (95) 61 (62) 10.43 (3.88–28.07) <.0001 Central 62 (68) 39 (40) 3.23 (1.78–5.88) .0001 Ventral 38 (42) 19 (19) 2.98 (1.55–5.72) .001 Dorsal 21 (23) 39 (40) 0.45 (0.24–0.86) .0145 Axial column lateral involvement <.0001 Lateral with additional columns 63 (69) 34 (35) Lateral only 23 (25) 27 (28) No lateral involved 5 (6) 37 (38) Median lesion size (mm) Axial A/P width 4.1 3.3 2.01 (1.49–2.72) <.0001 Transverse axial (mm3) 5.2 3.5 1.66 (1.36–2.01) <.0001 Area lesion 14.0 7.6 1.14 (1.08–1.2) <.0001 Note:—A/P indicates anterior-posterior.
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