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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurodegenerative Disorder Imaging

Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?

Jody Tanabe, Maili F. Lim, Siddhant Dash, Jack Pattee, Brandon Steach, Peter Pressman, Brianne M. Bettcher, Justin M. Honce, Valeria A. Potigailo, William Colantoni, David Zander and Ashesh A. Thaker
American Journal of Neuroradiology November 2024, 45 (11) 1737-1744; DOI: https://doi.org/10.3174/ajnr.A8406
Jody Tanabe
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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  • ORCID record for Jody Tanabe
Maili F. Lim
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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  • ORCID record for Maili F. Lim
Siddhant Dash
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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Jack Pattee
cCenter for Innovative Design and Analysis (J.P.), University of Colorado School of Public Health, Aurora, Colorado
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Brandon Steach
dicometrix (B.S.), Leuven, Belgium
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Peter Pressman
bDepartment of Neurology (P.P., B.M.B.), University of Colorado School of Medicine, Aurora, Colorado
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Brianne M. Bettcher
bDepartment of Neurology (P.P., B.M.B.), University of Colorado School of Medicine, Aurora, Colorado
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Justin M. Honce
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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Valeria A. Potigailo
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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William Colantoni
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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David Zander
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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Ashesh A. Thaker
aFrom the Department of Radiology (J.T., M.F.L., S.D., J.M.H., V.A.P., W.C., D.Z., A.A.T.), University of Colorado School of Medicine, Aurora, Colorado
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Article Figures & Data

Figures

  • Tables
  • FIG 1.
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    FIG 1.

    Patient-selection procedure. UCHealth indicates the large health system from which the data is drawn.

  • FIG 2.
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    FIG 2.

    Proportion of neuroradiologists’ exact and rough correct diagnoses with and without a quantitative report.

  • FIG 3.
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    FIG 3.

    Plot of coefficient estimates (ORs) and 95% CIs for exact and rough correct diagnoses within group in post hoc analysis. ORs >1 indicate that icometrix improves diagnostic accuracy.

  • FIG 4.
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    FIG 4.

    Boxplots of residualized volumes (blue = CN, green = FTD, red = AD). Compared with CN, both AD and FTD have significantly smaller residualized hippocampal volumes. A score of zero means there is no difference between patients’ volumes and the reference data set.

Tables

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    Table 1:

    Demographic and group characteristicsa

    AD (n = 22)FTD (n = 17)CN (n = 21)
    Age (yr)b71.4 (4.6) [61, 78]68.2 (10.0) [46, 82]75.0 (5.1) [68, 85]
    Male sex (%)6 (27%)9 (53%)13 (62%)
    Hypertensionb13 (59%)2 (12%)10 (48%)
    Diabetes5 (23%)1 (6%)5 (24%)
    MOCAb15.2 (7.4)18.4 (6.6)25.8 (2.8)
    • Note:—MOCA indicates Montreal Cognitive Assessment.

    • ↵a Data are mean (SD) [Min, Max].

    • ↵b P < .01.

    • View popup
    Table 2:

    Mean group differences, 95% CIs, and P values for residualized volumes

    Difference (AD-CN)Lower 95% CNUpper 95% CNP Value
    AD vs CN
     Whole brain−73.4−150.23.4.06
     Hippocampus−1.8−2.8−0.8<.001
     Frontal−1.8−20.617.0NS
     Parietal−6.1−18.56.3NS
     Temporal−10.5−23.52.5NS
     Occipital−2.6−8.12.8NS
    FTD vs CN
     Whole brain−66.4−148.515.8NS
     Hippocampus−1.2−2.2−0.10.02
     Frontal−9.5−29.610.6NS
     Parietal−0.4−13.612.9NS
     Temporal−6.5−20.47.4NS
     Occipital0.0−5.95.8NS
    FTD vs AD
     Whole brain7.0−74.388.3NS
     Hippocampus0.6−0.41.6NS
     Frontal−7.7−27.612.2NS
     Parietal5.7−7.418.8NS
     Temporal4.0−9.717.8NS
     Occipital2.6−3.28.3NS
    • Note:—NS indicates not significant.

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American Journal of Neuroradiology: 45 (11)
American Journal of Neuroradiology
Vol. 45, Issue 11
1 Nov 2024
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Cite this article
Jody Tanabe, Maili F. Lim, Siddhant Dash, Jack Pattee, Brandon Steach, Peter Pressman, Brianne M. Bettcher, Justin M. Honce, Valeria A. Potigailo, William Colantoni, David Zander, Ashesh A. Thaker
Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?
American Journal of Neuroradiology Nov 2024, 45 (11) 1737-1744; DOI: 10.3174/ajnr.A8406

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Automated Volumetric Software in Dementia
Jody Tanabe, Maili F. Lim, Siddhant Dash, Jack Pattee, Brandon Steach, Peter Pressman, Brianne M. Bettcher, Justin M. Honce, Valeria A. Potigailo, William Colantoni, David Zander, Ashesh A. Thaker
American Journal of Neuroradiology Nov 2024, 45 (11) 1737-1744; DOI: 10.3174/ajnr.A8406
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