Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleFunctional

Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy

N.L. Phillips, A.S. Shatil, C. Go, A. Robertson and E. Widjaja
American Journal of Neuroradiology July 2021, 42 (7) 1299-1304; DOI: https://doi.org/10.3174/ajnr.A7110
N.L. Phillips
aFrom the Neurosciences and Mental Health Program (N.L.P., A.S.S., A.R., E.W.), The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada
bDepartment of Psychology (N.L.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N.L. Phillips
A.S. Shatil
aFrom the Neurosciences and Mental Health Program (N.L.P., A.S.S., A.R., E.W.), The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.S. Shatil
C. Go
cDivision of Neurology (C.G., E.W.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Go
A. Robertson
aFrom the Neurosciences and Mental Health Program (N.L.P., A.S.S., A.R., E.W.), The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Robertson
E. Widjaja
aFrom the Neurosciences and Mental Health Program (N.L.P., A.S.S., A.R., E.W.), The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada
cDivision of Neurology (C.G., E.W.)
dDepartment of Diagnostic Imaging (E.W.), The Hospital for Sick Children, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Widjaja
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE.

    An 11-year-old child (A and B) with left-lateralized language on tb-fMRI and bilateral language on rs-fMRI. A 14-year-old adolescent (C and D) with bilateral language on tb-fMRI and left-lateralized language on rs-fMRI.

Tables

  • Figures
    • View popup
    Table 1:

    Language task-based fMRI tasks

    Language TaskDescription (Task and Control Condition)
    ADDTTask: decide whether a sentence is true or false and taps leg if correct.
    Control: listen to reverse speech and taps leg each time in response to hearing a beep
    ACTTask: decide whether a list of words falls into a previously presented category (eg, animals) and taps leg when target word matches category.
    Control: listen to reverse speech and taps leg each time in response to hearing a beep
    VFTask: generate words from a series of letters, ie, must generate as many words covertly/silently in head that begin with a particular letter (5 letters presented per task block via MR imaging goggle system).
    Control: constant right hand tapping during each 30-minute control block
    SWGTask: generate verbs from a series of nouns, ie, must generate as many verbs covertly/silently from each noun presented (5 nouns presented per task block via MR imaging goggle system).
    Control: constant left hand tapping during each 30-minute control block
    • View popup
    Table 2:

    Language laterality based on resting-state and task-based fMRI

    StudyLaterality
    LeftRightBilateral
    No.%No.%No.%
    Rs-fMRIa
     z = 1.53684%37%49%
     z = 2.53479%37%614%
     z = 33581%37%512%
    Tb-fMRIa
     ADDT, n = 403690%13%38%
     ACT, n = 433684%25%512%
     VF, n = 403280%13%718%
     SWG, n = 423583%12%614%
    • ↵a LI calculated with a cutoff score ± 0.2.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (7)
American Journal of Neuroradiology
Vol. 42, Issue 7
1 Jul 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
N.L. Phillips, A.S. Shatil, C. Go, A. Robertson, E. Widjaja
Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy
American Journal of Neuroradiology Jul 2021, 42 (7) 1299-1304; DOI: 10.3174/ajnr.A7110

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Resting-State Functional MRI for Determining Language Lateralization in Children with Drug-Resistant Epilepsy
N.L. Phillips, A.S. Shatil, C. Go, A. Robertson, E. Widjaja
American Journal of Neuroradiology Jul 2021, 42 (7) 1299-1304; DOI: 10.3174/ajnr.A7110
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Does white matter structure relate to hemispheric language lateralisation? A systematic review
  • In-Scanner Thoughts shape Resting-state Functional Connectivity: how participants "rest" matters
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more Functional

Pediatric Neuroimaging

  • Clinical SVR of Fetal Brain MRI
  • FRACTURE MR in Congenital Vertebral Anomalies
  • Comparing MRI Perfusion in Pediatric Brain Tumors
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire