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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Prolonged Microgravity Affects Human Brain Structure and Function

D.R. Roberts, D. Asemani, P.J. Nietert, M.A. Eckert, D.C. Inglesby, J.J. Bloomberg, M.S. George and T.R. Brown
American Journal of Neuroradiology November 2019, 40 (11) 1878-1885; DOI: https://doi.org/10.3174/ajnr.A6249
D.R. Roberts
aFrom the Departments of Radiology and Radiological Science (D.R.R., D.A., D.I., T.R.B.)
bDepartment of Neurosciences (D.R.R.)
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D. Asemani
aFrom the Departments of Radiology and Radiological Science (D.R.R., D.A., D.I., T.R.B.)
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P.J. Nietert
cPublic Health Sciences (P.J.N.)
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M.A. Eckert
dOtolaryngology–Head and Neck Surgery (M.A.E.)
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D.C. Inglesby
aFrom the Departments of Radiology and Radiological Science (D.R.R., D.A., D.I., T.R.B.)
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J.J. Bloomberg
fNeurosciences Laboratory (J.J.B.), NASA Johnson Space Center, Houston, Texas
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M.S. George
ePsychiatry and Behavioral Sciences (M.S.G.), Medical University of South Carolina, Charleston, South Carolina
gRalph H. Johnson VA Medical Center (M.S.G.), Charleston, South Carolina
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T.R. Brown
aFrom the Departments of Radiology and Radiological Science (D.R.R., D.A., D.I., T.R.B.)
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    Fig 1.

    Ventricular volume increases depended on duration in flight, type of space flight, and astronaut age (A–C). Note that the following modifications were made to the figures to protect astronaut anonymity: Individual data points for mission duration and ISS astronaut ages are not plotted. Instead, the regression line and 95% confidence bands are shown. A, Boxplot showing %ΔVV versus mission duration. B, %ΔVV versus mission duration, including Shuttle and ISS astronauts. C, %ΔVV versus ISS astronaut age at launch.

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    Fig 2.

    Spaceflight results in crowding of brain tissue at the vertex. Red voxels indicate regions along the brain surface where there was an increase in brain parenchyma pre- to postflight due to crowding of the brain tissue as the brain shifted upwards. Blue voxels indicate displaced brain tissue that occurred predominantly along the margins of the lateral and third ventricles due to enlargement of the ventricles postflight.

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    Fig 3.

    Regional deformation of brain parenchyma that significantly predicted performance on motor function tests. A, Regional deformation of brain parenchyma that significantly predicted performance on the Recovery from Fall/Stand Test (P < .05). B, Regional deformation of brain parenchyma that significantly predicted performance on the Dynamic Postural Stability Test (P < .05). C, Regional deformation of brain parenchyma that significantly predicted performance on the Seated Egress and Walk Test (P < .05).

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    Fig 4.

    Regional deformation of brain parenchyma that significantly predicted performance on the Continuous Performance Test (P < .05).

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American Journal of Neuroradiology: 40 (11)
American Journal of Neuroradiology
Vol. 40, Issue 11
1 Nov 2019
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D.R. Roberts, D. Asemani, P.J. Nietert, M.A. Eckert, D.C. Inglesby, J.J. Bloomberg, M.S. George, T.R. Brown
Prolonged Microgravity Affects Human Brain Structure and Function
American Journal of Neuroradiology Nov 2019, 40 (11) 1878-1885; DOI: 10.3174/ajnr.A6249

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Prolonged Microgravity Affects Human Brain Structure and Function
D.R. Roberts, D. Asemani, P.J. Nietert, M.A. Eckert, D.C. Inglesby, J.J. Bloomberg, M.S. George, T.R. Brown
American Journal of Neuroradiology Nov 2019, 40 (11) 1878-1885; DOI: 10.3174/ajnr.A6249
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