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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatrics
Open Access

Signal Change in the Mammillary Bodies after Perinatal Asphyxia

M. Molavi, S.D. Vann, L.S. de Vries, F. Groenendaal and M. Lequin
American Journal of Neuroradiology November 2019, 40 (11) 1829-1834; DOI: https://doi.org/10.3174/ajnr.A6232
M. Molavi
aFrom the Departments of Radiology and Neonatology (M.M., L.S.d.V., F.G., M.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands
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S.D. Vann
bSchool of Psychology (S.D.V.), Cardiff University, Cardiff, UK
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L.S. de Vries
aFrom the Departments of Radiology and Neonatology (M.M., L.S.d.V., F.G., M.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands
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  • ORCID record for L.S. de Vries
F. Groenendaal
aFrom the Departments of Radiology and Neonatology (M.M., L.S.d.V., F.G., M.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands
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M. Lequin
aFrom the Departments of Radiology and Neonatology (M.M., L.S.d.V., F.G., M.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands
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  • Fig 1.
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    Fig 1.

    Schematic of the extended Papez system highlighting the principal connections of the mammillary bodies.

  • Fig 2.
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    Fig 2.

    Arrows indicate the following: abnormally high-signal MBs on an axial T2-weighted image (A); abnormally low-signal MBs on an axial T1-weighted image (B); and abnormally high-signal MBs on DWI, b-value = 1000, accompanied by low ADC (not shown) (C).

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    Fig 3.

    Sagittal T1-weighted MR imaging. The arrows indicate abnormal, low signal in MBs at 6 days (A) and MB atrophy at 3 (B) and 19 (C) months.

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    Fig 4.

    Day (postbirth) of initial MR imaging in patients with hypothermia treatment or without (normothermia). The day of scanning was typically days 5–7 for the hypothermia-treated patients, whereas there was a greater range of scanning days for patients with normothermia.

Tables

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    Table 1:

    General demographic and clinical findings of neonates with high MB signal on T2-weighted images

    Cases with T2-Weighted High-Signal MB (n = 31)
    Sex, male/female15:16
    Gestational age (mean) (wk)40 ± 2.0
    Birth weight (mean) (kg)3113 ± 556
    Apgar 1 min (median) (IQR)2 (3)
    Apgar 5 min (median) (IQR)5 (4)
    Age at first MR imaging in days after birth (median) (IQR)6 (2)
    Field strength of MR imaging (1.5T/3T)17/14
    Grade of encephalopathy (Sarnat I/II/III)4/25/2
    Hypothermia (%)18 (58)
    Died (%)4 (13)
    Normal findings on clinical follow-up (%)21 (68)
    Abnormal findings on clinical follow-up (%)5 (16)
    Severe hyponatremia (<130 mEq/L) (%)8 (26)
    Systemic infection (%)3 (10)
    • Note:—IQR indicates interquartile range.

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    Table 2:

    MR imaging pattern of hypoxic-ischemic lesions

    Pattern
    NL13 (41.9%)
    BGT5 (16.1%)
    WS9 (29%)
    NT3 (9.7%)
    Large subdural hematoma1 (3.2%)
    Total31
    • Note:—NL indicates normal; BGT, basal ganglia and thalamus; WS, watershed; NT, near total.

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    Table 3:

    Involvement of additional structures within the Papez circuit

    Additional Structures
    F1
    HC4
    AT0
    CG1
    AT/F1
    HC/F7
    More than 2 involved4
    None13 (41.9%)
    Total31
    • Note:—F indicates fornix; HC, hippocampus; AT, anterior thalamus; CG, cingulate gyrus.

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American Journal of Neuroradiology: 40 (11)
American Journal of Neuroradiology
Vol. 40, Issue 11
1 Nov 2019
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Cite this article
M. Molavi, S.D. Vann, L.S. de Vries, F. Groenendaal, M. Lequin
Signal Change in the Mammillary Bodies after Perinatal Asphyxia
American Journal of Neuroradiology Nov 2019, 40 (11) 1829-1834; DOI: 10.3174/ajnr.A6232

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Signal Change in the Mammillary Bodies after Perinatal Asphyxia
M. Molavi, S.D. Vann, L.S. de Vries, F. Groenendaal, M. Lequin
American Journal of Neuroradiology Nov 2019, 40 (11) 1829-1834; DOI: 10.3174/ajnr.A6232
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    American Journal of Neuroradiology 2022 43 6
  • Outcome of non-cooled asphyxiated infants with under-recognised or delayed-onset encephalopathy
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    Archives of Disease in Childhood - Fetal and Neonatal Edition 2022 107 4
  • Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies
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  • Mammillary Body and Hippocampal Injury After Acute Perinatal Arterial Ischemic Stroke
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  • Update on MRI Assessment of Neonatal Hypoxic-Ischemic Encephalopathy
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    Japanese Journal of Magnetic Resonance in Medicine 2022 42 4

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