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Research ArticlePatient Safety

Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol

J.R. Young, W.B. Pope and M. Bobinski
American Journal of Neuroradiology September 2018, 39 (9) 1604-1608; DOI: https://doi.org/10.3174/ajnr.A5748
J.R. Young
aFrom the Department of Radiology (J.R.Y., M.B.), University of California Davis School of Medicine, Sacramento, California
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W.B. Pope
bDepartment of Radiology (W.B.P.), David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California.
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M. Bobinski
aFrom the Department of Radiology (J.R.Y., M.B.), University of California Davis School of Medicine, Sacramento, California
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References

  1. 1.↵
    1. Adin ME,
    2. Kleinberg L,
    3. Vaidya D, et al
    . Hyperintense dentate nuclei on T1-weighted MRI: relation to repeat gadolinium administration. AJNR Am J Neuroradiol 2015;36:1859–65 doi:10.3174/ajnr.A4378 pmid:26294649
    Abstract/FREE Full Text
  2. 2.↵
    1. Errante Y,
    2. Cirimele V,
    3. Mallio CA, et al
    . Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol 2014;49:685–90 doi:10.1097/RLI.0000000000000072 pmid:24872007
    CrossRefPubMed
  3. 3.↵
    1. Kanda T,
    2. Ishii K,
    3. Kawaguchi H, et al
    . High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 2014;270:834–41 doi:10.1148/radiol.13131669 pmid:24475844
    CrossRefPubMed
  4. 4.↵
    1. Kanda T,
    2. Osawa M,
    3. Oba H, et al
    . High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: association with linear versus macrocyclic gadolinium chelate administration. Radiology 2015;275:803–09 doi:10.1148/radiol.14140364 pmid:25633504
    CrossRefPubMed
  5. 5.↵
    1. McDonald RJ,
    2. McDonald JS,
    3. Kallmes DF, et al
    . Intracranial gadolinium deposition after contrast-enhanced MR imaging. Radiology 2015;275:772–82 doi:10.1148/radiol.15150025 pmid:25742194
    CrossRefPubMed
  6. 6.↵
    1. McDonald RJ,
    2. McDonald JS,
    3. Kallmes DF, et al
    . Gadolinium deposition in human brain tissues after contrast-enhanced MR imaging in adult patients without intracranial abnormalities. Radiology 2017;285:546–54 doi:10.1148/radiol.2017161595 pmid:28653860
    CrossRefPubMed
  7. 7.↵
    1. Quattrocchi CC,
    2. Mallio CA,
    3. Errante Y, et al
    . Gadodiamide and dentate nucleus T1 hyperintensity in patients with meningioma evaluated by multiple follow-up contrast-enhanced magnetic resonance examinations with no systemic interval therapy. Invest Radiol 2015;50:470–72 doi:10.1097/RLI.0000000000000154 pmid:25756685
    CrossRefPubMed
  8. 8.↵
    1. Radbruch A,
    2. Weberling LD,
    3. Kieslich PJ, et al
    . Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 2015;275:783–91 doi:10.1148/radiol.2015150337 pmid:25848905
    CrossRefPubMed
  9. 9.↵
    1. Ramalho J,
    2. Castillo M,
    3. AlObaidy M, et al
    . High signal intensity in globus pallidus and dentate nucleus on unenhanced T1-weighted MR images: evaluation of two linear gadolinium-based contrast agents. Radiology 2015;276:836–44 doi:10.1148/radiol.2015150872 pmid:26079490
    CrossRefPubMed
  10. 10.↵
    1. Flood TF,
    2. Stence NV,
    3. Maloney JA, et al
    . Pediatric brain: repeated exposure to linear gadolinium-based contrast material is associated with increased signal intensity at unenhanced T1-weighted MR imaging. Radiology 2017;282:222–28 doi:10.1148/radiol.2016160356 pmid:27467467
    CrossRefPubMed
  11. 11.↵
    1. Roberts DR,
    2. Chatterjee AR,
    3. Yazdani M, et al
    . Pediatric patients demonstrate progressive T1-weighted hyperintensity in the dentate nucleus following multiple doses of gadolinium-based contrast agent. AJNR Am J Neuroradiol 2016;37:2340–47 doi:10.3174/ajnr.A4891 pmid:27469211
    Abstract/FREE Full Text
  12. 12.↵
    1. Hu HH,
    2. Pokorney A,
    3. Towbin RB, et al
    . Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams. Pediatr Radiol 2016;46:1590–98 doi:10.1007/s00247-016-3646-3 pmid:27282825
    CrossRefPubMed
  13. 13.↵
    1. Young JR,
    2. Orosz I,
    3. Franke MA, et al
    . Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration. Clin Radiol 2018;73:290–95 doi:10.1016/j.crad.2017.11.005 pmid:29208312
    CrossRefPubMed
  14. 14.↵
    1. Radbruch A,
    2. Haase R,
    3. Kickingereder P, et al
    . Pediatric brain: no increased signal intensity in the dentate nucleus on unenhanced T1-weighted MR images after consecutive exposure to a macrocyclic gadolinium-based contrast agent. Radiology 2017;283:828–36 doi:10.1148/radiol.2017162980 pmid:28273007
    CrossRefPubMed
  15. 15.↵
    1. Tibussek D,
    2. Rademacher C,
    3. Caspers J, et al
    . Gadolinium brain deposition after macrocyclic gadolinium administration: a pediatric case-control study. Radiology 2017;285:223–30 doi:10.1148/radiol.2017161151 pmid:28640695
    CrossRefPubMed
  16. 16.↵
    1. Rossi Espagnet MC,
    2. Bernardi B,
    3. Pasquini L, et al
    . Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children. Pediatr Radiol 2017;47:1345–52 doi:10.1007/s00247-017-3874-1 pmid:28526896
    CrossRefPubMed
  17. 17.↵
    1. Blakemore SJ
    . Imaging brain development: the adolescent brain. Neuroimage 2012;61:397–406 doi:10.1016/j.neuroimage.2011.11.080 pmid:22178817
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Stein J,
    2. Schettler T,
    3. Wallinga D, et al
    . In harm's way: toxic threats to child development. J Dev Behav Pediatr 2002;23:S13–22 doi:10.1097/00004703-200202001-00004 pmid:11875286
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Radbruch A,
    2. Quattrocchi CC
    . Interpreting signal-intensity ratios without visible T1 hyperintensities in clinical gadolinium retention studies. Pediatr Radiol 2017;47:1688–89 doi:10.1007/s00247-017-3970-2 pmid:28914340
    CrossRefPubMed
  20. 20.↵
    1. Radbruch A,
    2. Haase R,
    3. Kieslich PJ, et al
    . No signal intensity increase in the dentate nucleus on unenhanced T1-weighted MR images after more than 20 serial injections of macrocyclic gadolinium-based contrast agents. Radiology 2017;282:699–707 doi:10.1148/radiol.2016162241 pmid:27925871
    CrossRefPubMed
  21. 21.↵
    1. Ramalho J,
    2. Ramalho M,
    3. AlObaidy M, et al
    . Technical aspects of MRI signal change quantification after gadolinium-based contrast agents' administration. Magn Reason Imaging 2016;34:1355–58 doi:10.1016/j.mri.2016.09.004 pmid:27693606
    CrossRefPubMed
  22. 22.↵
    1. Hinoda T,
    2. Fushimi Y,
    3. Okada T, et al
    . Quantitative assessment of gadolinium deposition in dentate nucleus using quantitative susceptibility mapping. J Magn Reason Imaging 2017;45:1352–58 doi:10.1002/jmri.25490 pmid:27664936
    CrossRefPubMed
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American Journal of Neuroradiology: 39 (9)
American Journal of Neuroradiology
Vol. 39, Issue 9
1 Sep 2018
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J.R. Young, W.B. Pope, M. Bobinski
Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol
American Journal of Neuroradiology Sep 2018, 39 (9) 1604-1608; DOI: 10.3174/ajnr.A5748

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Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol
J.R. Young, W.B. Pope, M. Bobinski
American Journal of Neuroradiology Sep 2018, 39 (9) 1604-1608; DOI: 10.3174/ajnr.A5748
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