Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Longitudinal Persistence of Meningeal Enhancement on Postcontrast 7T 3D-FLAIR MRI in Multiple Sclerosis

S.N. Jonas, I. Izbudak, A.A. Frazier and D.M. Harrison
American Journal of Neuroradiology October 2018, 39 (10) 1799-1805; DOI: https://doi.org/10.3174/ajnr.A5796
S.N. Jonas
aFrom the Department of Radiology (S.N.J., A.A.F.), University of Maryland Medical Center, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.N. Jonas
I. Izbudak
bDepartment of Radiology/Neuroradiology (I.I), Johns Hopkins University, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for I. Izbudak
A.A. Frazier
aFrom the Department of Radiology (S.N.J., A.A.F.), University of Maryland Medical Center, Baltimore, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.A. Frazier
D.M. Harrison
cDepartment of Neurology, University of Maryland School of Medicine (D.M.H.), Baltimore, Maryland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.M. Harrison
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Magliozzi R,
    2. Howell O,
    3. Vora A, et al
    . Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain J Neurol 2007;130(Pt 4):1089–104 pmid:17438020
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Lucchinetti CF,
    2. Popescu BF,
    3. Bunyan RF, et al
    . Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med 2011;365:2188–97 doi:10.1056/NEJMoa1100648 pmid:22150037
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Choi SR,
    2. Howell OW,
    3. Carassiti D, et al
    . Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain J Neurol 2012;135(Pt 10):2925–37 doi:10.1093/brain/aws189 pmid:22907116
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Serafini B,
    2. Rosicarelli B,
    3. Magliozzi R, et al
    . Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004;14:164–74 doi:10.1111/j.1750-3639.2004.tb00049.x pmid:15193029
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Kowarik MC,
    2. Cepok S,
    3. Sellner J, et al
    . CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation. J Neuroinflammation 2012;9:93 doi:10.1186/1742-2094-9-93 pmid:22591862
    CrossRefPubMed
  6. 6.↵
    1. Nielsen AS,
    2. Kinkel RP,
    3. Tinelli E, et al
    . Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2. J Magn Reson Imaging 2012;35:537–42 doi:10.1002/jmri.22847 pmid:22045554
    CrossRefPubMed
  7. 7.↵
    1. Absinta M,
    2. Vuolo L,
    3. Rao A, et al
    . Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis. Neurology 2015;85:18–28 doi:10.1212/WNL.0000000000001587 pmid:25888557
    Abstract/FREE Full Text
  8. 8.↵
    1. Zivadinov R,
    2. Ramasamy DP,
    3. Hagemeier J, et al
    . Evaluation of leptomeningeal contrast enhancement using pre-and postcontrast subtraction 3D-FLAIR imaging in multiple sclerosis. AJNR Am J Neuroradiol 2018;39:642–47 doi:10.3174/ajnr.A5541 pmid:29439125
    Abstract/FREE Full Text
  9. 9.↵
    1. Harrison DM,
    2. Wang KY,
    3. Fiol J, et al
    . Leptomeningeal enhancement at 7T in multiple sclerosis: frequency, morphology, and relationship to cortical volume. J Neuroimaging 2017;27:461–68 doi:10.1111/jon.12444 pmid:28464368
    CrossRefPubMed
  10. 10.↵
    1. Howell OW,
    2. Reeves CA,
    3. Nicholas R, et al
    . Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain J Neurol 2011;134(Pt 9):2755–71 doi:10.1093/brain/awr182 pmid:21840891
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Howell OW,
    2. Schulz-Trieglaff EK,
    3. Carassiti D, et al
    . Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space. Neuropathol Appl Neurobiol 2015;41:798–813 doi:10.1111/nan.12199 pmid:25421634
    CrossRefPubMed
  12. 12.↵
    1. Polman CH,
    2. Reingold SC,
    3. Banwell B, et al
    . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292–302 doi:10.1002/ana.22366 pmid:21387374
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Haines K,
    2. Smith NB,
    3. Webb AG
    . New high dielectric constant materials for tailoring the B1+ distribution at high magnetic fields. J Magn Reson 2010;203:323–27 doi:10.1016/j.jmr.2010.01.003 pmid:20122862
    CrossRefPubMed
  14. 14.↵
    1. Marques JP,
    2. Kober T,
    3. Krueger G, et al
    . MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. Neuroimage 2010;49:1271–81 doi:10.1016/j.neuroimage.2009.10.002 pmid:19819338
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Tustison NJ,
    2. Avants BB,
    3. Cook PA, et al
    . N4ITK: improved N3 bias correction. IEEE Trans Med Imaging 2010;29:1310–20 doi:10.1109/TMI.2010.2046908 pmid:20378467
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Kurtzke JF
    . Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444–52 doi:10.1212/WNL.33.11.1444 pmid:6685237
    Abstract/FREE Full Text
  17. 17.↵
    Multiple Sclerosis Council for Clinical Practice Guidelines. Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis. Paralyzed Veterans of America 1998:1–33
  18. 18.↵
    1. Flachenecker P,
    2. Kumpfel T,
    3. Kallmann B, et al
    . Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler 2002;8:523–26 doi:10.1191/1352458502ms839oa pmid:12474995
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Smith A
    . Symbol Digit Modalities Test: Manual. Los Angeles: Western Psychological Services; 1973
  20. 20.↵
    1. Aspelund A,
    2. Antila S,
    3. Proulx ST, et al
    . A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 2015;212:991–99 doi:10.1084/jem.20142290 pmid:26077718
    Abstract/FREE Full Text
  21. 21.↵
    1. Raper D,
    2. Louveau A,
    3. Kipnis J
    . How do meningeal lymphatic vessels drain the CNS? Trends Neurosci 2016;39:581–86 doi:10.1016/j.tins.2016.07.001 pmid:27460561
    CrossRefPubMed
  22. 22.↵
    1. Absinta M,
    2. Ha SK,
    3. Nair G, et al
    . Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elif 2017;6 doi:10.7554/eLife.29738 pmid:28971799
    CrossRefPubMed
  23. 23.↵
    1. Plog BA,
    2. Nedergaard M
    . The glymphatic system in central nervous system health and disease: past, present, and future. Annu Rev Pathol 2018;13:379–94 doi:10.1146/annurev-pathol-051217-111018 pmid:29195051
    CrossRefPubMed
  24. 24.↵
    1. Ortiz GG,
    2. Pacheco-Moisés FP,
    3. Macías-Islas MA, et al
    . Role of the blood-brain barrier in multiple sclerosis. Arch Med Res 2014;45:687–97 doi:10.1016/j.arcmed.2014.11.013 pmid:25431839
    CrossRefPubMed
  25. 25.↵
    1. Zivadinov R,
    2. Ramasamy DP,
    3. Vaneckova M, et al
    . Leptomeningeal contrast enhancement is associated with progression of cortical atrophy in MS: a retrospective, pilot, observational longitudinal study. Mult Scler 2017;23:1336–45 doi:10.1177/1352458516678083 pmid:27811339
    CrossRefPubMed
  26. 26.↵
    1. Absinta M,
    2. Cortese IC,
    3. Vuolo L, et al
    . Leptomeningeal gadolinium enhancement across the spectrum of chronic neuroinflammatory diseases. Neurology 2017;88:1439–44 doi:10.1212/WNL.0000000000003820 pmid:28283598
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 39 (10)
American Journal of Neuroradiology
Vol. 39, Issue 10
1 Oct 2018
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Longitudinal Persistence of Meningeal Enhancement on Postcontrast 7T 3D-FLAIR MRI in Multiple Sclerosis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S.N. Jonas, I. Izbudak, A.A. Frazier, D.M. Harrison
Longitudinal Persistence of Meningeal Enhancement on Postcontrast 7T 3D-FLAIR MRI in Multiple Sclerosis
American Journal of Neuroradiology Oct 2018, 39 (10) 1799-1805; DOI: 10.3174/ajnr.A5796

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Longitudinal Persistence of Meningeal Enhancement on Postcontrast 7T 3D-FLAIR MRI in Multiple Sclerosis
S.N. Jonas, I. Izbudak, A.A. Frazier, D.M. Harrison
American Journal of Neuroradiology Oct 2018, 39 (10) 1799-1805; DOI: 10.3174/ajnr.A5796
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Meningeal contrast enhancement in multiple sclerosis: assessment of field strength, acquisition delay, and clinical relevance
  • Leptomeningeal Enhancement in Multiple Sclerosis and Other Neurological Diseases: A Systematic Review and Meta-Analysis
  • Leptomeningeal Contrast Enhancement Is Related to Focal Cortical Thinning in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional MRI Study
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire