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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleInterventional
Open Access

Hemodynamic Changes Caused by Multiple Stenting in Vertebral Artery Fusiform Aneurysms: A Patient-Specific Computational Fluid Dynamics Study

N. Lv, W. Cao, I. Larrabide, C. Karmonik, D. Zhu, J. Liu, Q. Huang and Y. Fang
American Journal of Neuroradiology January 2018, 39 (1) 118-122; DOI: https://doi.org/10.3174/ajnr.A5452
N. Lv
aFrom the Department of Neurosurgery (N.V., W.C., D.Z., Y.F., Q.H., J.L.), Changhai Hospital, Second Military Medical University, Shanghai, China
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W. Cao
aFrom the Department of Neurosurgery (N.V., W.C., D.Z., Y.F., Q.H., J.L.), Changhai Hospital, Second Military Medical University, Shanghai, China
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I. Larrabide
bNational Scientific and Technical Research Council of Argentina (I.L.), Buenos Aires, Argentina
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C. Karmonik
cMRI Core (C.K.), Houston Methodist Research Institute, Houston, Texas.
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D. Zhu
aFrom the Department of Neurosurgery (N.V., W.C., D.Z., Y.F., Q.H., J.L.), Changhai Hospital, Second Military Medical University, Shanghai, China
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J. Liu
aFrom the Department of Neurosurgery (N.V., W.C., D.Z., Y.F., Q.H., J.L.), Changhai Hospital, Second Military Medical University, Shanghai, China
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Q. Huang
aFrom the Department of Neurosurgery (N.V., W.C., D.Z., Y.F., Q.H., J.L.), Changhai Hospital, Second Military Medical University, Shanghai, China
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Y. Fang
aFrom the Department of Neurosurgery (N.V., W.C., D.Z., Y.F., Q.H., J.L.), Changhai Hospital, Second Military Medical University, Shanghai, China
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    Fig 1.

    Process of virtual stent deployment. A–C, Three virtual Enterprise stents were deployed one by one. D and E, Location of real stents in 2D angiography and DynaCT (Siemens). F, Virtual stents deployed in a similar location with the real counterparts.

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    Fig 2.

    Box figure of hemodynamic analysis results. The asterisk indicates that the parameter was significantly different from the prestenting status.

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    Fig 3.

    Flow patterns of 2 vertebral artery fusiform cases with different stent-placement strategies. One and 2 represent 2 individual cases. From left to right, flow patterns before and after implantation of 1–3 stents. The yellow dotted lines represent the positions of the stents. As the number of stents increased, blood flow inside the stent lumen concentrated and the flow rate accelerated, while the flow rate inside the aneurysmal sacs slowed and the vortex intensity weakened.

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    Table 1:

    Clinical data of 10 patients with VAFAs

    Patient No.Age (yr)SexRupturedTreatmentFollow-Up
    Case 146MaleNo3 EP8 mo, cured
    Case 253MaleNo2 EP12 mo, thrombosis formation
    Case 339FemaleYes2 EP+coilsWithdraw
    Case 437MaleYes2 EP+coils6 mo, cured
    Case 551MaleNo2 EP+coils7 mo, thrombosis formation
    Case 659MaleNo3 EP13 mo, cured
    Case 749FemaleYes2 EP+coils12 mo, cured
    Case 846MaleYes3 EP+coils12 mo, cured
    Case 960MaleNo2 EP6 mo, stable
    Case1046MaleNo2 EP12 mo, thrombosis formation
    • Note:—EP indicates Enterprise self-expanding stent.

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    Table 2:

    Hemodynamic parameters of VAFAs with different stenting strategiesa

    Parameters0 Stent1 Stent2 Stents3 StentsP Value
    Wall shear stress (%) (n = 10)10092.879.474.2.003
    Oscillatory shear index (%) (n = 10)10056.550.562.6.169
    Pressure (%) (n = 10)100115.7121.5128.2<.001
    Relative residence time (%) (n = 10)100111.3115.4145.0.004
    • ↵a Data are expressed as the median of the variation rate.

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    Table 3:

    P values of multiple comparisons among different stenting strategies

    Parameters0 Stent vs 1 Stent0 Stent vs 2 Stents0 Stent vs 3 Stents
    WSS (n = 10).498.063.007
    Pressure (n = 10).037.001<.001
    RRT (n = 10).904.251.009
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American Journal of Neuroradiology: 39 (1)
American Journal of Neuroradiology
Vol. 39, Issue 1
1 Jan 2018
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Cite this article
N. Lv, W. Cao, I. Larrabide, C. Karmonik, D. Zhu, J. Liu, Q. Huang, Y. Fang
Hemodynamic Changes Caused by Multiple Stenting in Vertebral Artery Fusiform Aneurysms: A Patient-Specific Computational Fluid Dynamics Study
American Journal of Neuroradiology Jan 2018, 39 (1) 118-122; DOI: 10.3174/ajnr.A5452

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Hemodynamic Changes Caused by Multiple Stenting in Vertebral Artery Fusiform Aneurysms: A Patient-Specific Computational Fluid Dynamics Study
N. Lv, W. Cao, I. Larrabide, C. Karmonik, D. Zhu, J. Liu, Q. Huang, Y. Fang
American Journal of Neuroradiology Jan 2018, 39 (1) 118-122; DOI: 10.3174/ajnr.A5452
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  • Comparing the safety and effectiveness of overlapping stents with flow diverters for unruptured vertebral artery dissecting aneurysms
  • Predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs): results from a multicenter study
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