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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Relationship between Glioblastoma Heterogeneity and Survival Time: An MR Imaging Texture Analysis

Y. Liu, X. Xu, L. Yin, X. Zhang, L. Li and H. Lu
American Journal of Neuroradiology September 2017, 38 (9) 1695-1701; DOI: https://doi.org/10.3174/ajnr.A5279
Y. Liu
aFrom the School of Biomedical Engineering (Y.L., X.P.X., L.L.Y., X.Z., H.B.L.), Fourth Military Medical University, Xi'an, Shaanxi, China
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  • ORCID record for Y. Liu
X. Xu
aFrom the School of Biomedical Engineering (Y.L., X.P.X., L.L.Y., X.Z., H.B.L.), Fourth Military Medical University, Xi'an, Shaanxi, China
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L. Yin
aFrom the School of Biomedical Engineering (Y.L., X.P.X., L.L.Y., X.Z., H.B.L.), Fourth Military Medical University, Xi'an, Shaanxi, China
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X. Zhang
aFrom the School of Biomedical Engineering (Y.L., X.P.X., L.L.Y., X.Z., H.B.L.), Fourth Military Medical University, Xi'an, Shaanxi, China
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L. Li
aFrom the School of Biomedical Engineering (Y.L., X.P.X., L.L.Y., X.Z., H.B.L.), Fourth Military Medical University, Xi'an, Shaanxi, China
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H. Lu
bDepartment of Engineering Science and Physics (L.H.L.), City University of New York at College of Staten Island, Staten Island, New York.
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    Fig 1.

    The schematic diagram for data processing and analysis.

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    Fig 2.

    ROC curves of the different feature combinations with the SVM classifier (CM, RLM, and Hist stand for the co-occurrence matrix, run-length matrix, and histogram-based texture types, respectively).

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    Fig 3.

    Optimal feature subset selection. A, Selection process of the optimal feature subset with RFE-SVM. B, ROC curve of the optimal feature subset selected.

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    Fig 4.

    Ranking orders of all features in the optimal subset. The length of each bar represents the iteration number at which the feature was rejected by the RFE.

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    Fig 5.

    Kaplan-Meier survival curves determined by the log-rank test (P < .001).

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    Table 1:

    Summary of patient characteristics of long- and short-term groups

    GroupSex (Male/Female)Age (Median, Range) (yr)Overall Survival (Median, Range) (days)
    Long-term group40:2759, 14∼81600, 370∼1731
    Short-term group43:2364, 17∼85145, 16∼357
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    Table 2:

    Texture features extracted from ROIs of GBM images

    Feature Group/Feature IDDescription
    CM features
        CM1Energy
        CM2Contrast
        CM3Correlation
        CM4Variance
        CM5Inverse difference moment
        CM6Sum average
        CM7Sum variance
        CM8Sum entropy
        CM9Entropy
        CM10Difference variance
        CM11Difference entropy
        CM12Information measures I of correlation
        CM13Information measures II of correlation
        RCM1–RCM13Range of corresponding features listed above
    RLM features
        RLM1Short-run emphasis
        RLM2Long-run emphasis
        RLM3Gray-level nonuniformity
        RLM4Run-length nonuniformity
        RLM5Run percentage
        RLM6Low gray-level run emphasis
        RLM7High gray-level run emphasis
        RLM8Short-run low gray-level emphasis
        RLM9Short-run high gray-level emphasis
        RLM10Long-run low gray-level emphasis
        RLM11Long-run high gray-level emphasis
        RRLM1–RRLM11Range of corresponding features listed above
    Histogram-based features
        H1Mean
        H2Entropy
        H3Uniformity
        H4SD
        H5Smoothness
        H6Skewness
        H7Third-order moment
        H8Kurtosis
    • Note:—ID indicates identification; RCM, range of co-occurrence matrix; RRLM, range of run-length matrix; H, histogram.

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    Table 3:

    The performance of feature combinations with the SVM classifier in differentiating long- and short-term survival time

    Feature SetNFaSVM
    SensitivitySpecificityAccuracyAUC
    CMb260.79100.66670.72930.7786
    RLM220.73130.42420.57890.5880
    Histogram80.68660.25760.47370.4326
    CM + RLMb480.77610.77270.77440.8053
    CM + histogram340.77610.68180.72930.7782
    RLM + histogram300.80600.37880.59400.6223
    CM + RLM + histogramc560.77610.78790.78200.8057
    • Note:—AUC indicates area under the curve.

    • ↵a The number of features in each subset.

    • ↵b The best classification when the feature type is used alone or pair-combined.

    • ↵c The best classification result when all features are used.

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American Journal of Neuroradiology: 38 (9)
American Journal of Neuroradiology
Vol. 38, Issue 9
1 Sep 2017
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Cite this article
Y. Liu, X. Xu, L. Yin, X. Zhang, L. Li, H. Lu
Relationship between Glioblastoma Heterogeneity and Survival Time: An MR Imaging Texture Analysis
American Journal of Neuroradiology Sep 2017, 38 (9) 1695-1701; DOI: 10.3174/ajnr.A5279

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Relationship between Glioblastoma Heterogeneity and Survival Time: An MR Imaging Texture Analysis
Y. Liu, X. Xu, L. Yin, X. Zhang, L. Li, H. Lu
American Journal of Neuroradiology Sep 2017, 38 (9) 1695-1701; DOI: 10.3174/ajnr.A5279
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