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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Incidental Findings in Youths Volunteering for Brain MRI Research

R.E. Gur, D. Kaltman, E.R. Melhem, K. Ruparel, K. Prabhakaran, M. Riley, E. Yodh, H. Hakonarson, T. Satterthwaite and R.C. Gur
American Journal of Neuroradiology October 2013, 34 (10) 2021-2025; DOI: https://doi.org/10.3174/ajnr.A3525
R.E. Gur
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
bDivision of Neuroradiology (R.E.G., E.R.M., R.C.G.), Department of Radiology, Perlman School of Medicine, University of Pennsylvania, Philadelphia
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D. Kaltman
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
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E.R. Melhem
bDivision of Neuroradiology (R.E.G., E.R.M., R.C.G.), Department of Radiology, Perlman School of Medicine, University of Pennsylvania, Philadelphia
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K. Ruparel
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
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K. Prabhakaran
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
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M. Riley
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
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E. Yodh
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
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H. Hakonarson
cCenter for Applied Genomics (H.H.), Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
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T. Satterthwaite
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
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R.C. Gur
aFrom the Brain Behavior Laboratory (R.E.G., D.K., K.R., K.P., M.R., E.Y., T.S., R.C.G.), Department of Psychiatry
bDivision of Neuroradiology (R.E.G., E.R.M., R.C.G.), Department of Radiology, Perlman School of Medicine, University of Pennsylvania, Philadelphia
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    Fig 1.

    Examples of incidental findings categories. A, Pineal cyst; B, other cysts; C, cavum septum pellucidum; D, ventricular abnormalities; E, vascular abnormalities; F, cerebellar abnormalities.

Tables

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    Table 1:

    Sample demographics by group

    Participant CharacteristicNormal Finding Group (n = 1252)Incidental Finding Group (n = 148)
    Age, y14.72 ± 3.5914.85 ± 3.92
    Education, y7.64 ± 3.507.81 ± 3.77
    Sex, %
        Male4849
        Female5251
    Race, %
        White4549
        African American4240
        Other1311
    • View popup
    Table 2:

    Frequency of incidental findings

    FindingCountPrevalenceLiterature
    Pineal cyst342.43%1–10%
    Other cyst191.36%1–15%
    Cavum septum pellucidum161.14%1–20+%
    Other CSF abnormalities332.36%N/A
    Vascular abnormalities362.57%N/A
    Cerebellar abnormalities332.36%1–3% ectopia
    Coincidental1369.71%2–20%
    All incidental14810.57%3–85%
    • The literature values are mostly from adults. Counts do not add to 148 because some subjects have more than 1 finding.

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American Journal of Neuroradiology: 34 (10)
American Journal of Neuroradiology
Vol. 34, Issue 10
1 Oct 2013
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Incidental Findings in Youths Volunteering for Brain MRI Research
R.E. Gur, D. Kaltman, E.R. Melhem, K. Ruparel, K. Prabhakaran, M. Riley, E. Yodh, H. Hakonarson, T. Satterthwaite, R.C. Gur
American Journal of Neuroradiology Oct 2013, 34 (10) 2021-2025; DOI: 10.3174/ajnr.A3525
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R.E. Gur, D. Kaltman, E.R. Melhem, K. Ruparel, K. Prabhakaran, M. Riley, E. Yodh, H. Hakonarson, T. Satterthwaite, R.C. Gur
Incidental Findings in Youths Volunteering for Brain MRI Research
American Journal of Neuroradiology Oct 2013, 34 (10) 2021-2025; DOI: 10.3174/ajnr.A3525

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