Article Figures & Data
Figures
- Fig 1.
Example of the selection of ROIs from 8 structures under study in 1 of the subjects. A−D, ADC maps. E−H, FA maps.
- Fig 2.
ADC maps and T2WI and isotropic DWI images before acute alcohol consumption and 1 hour after the acute alcohol administration in a 25-year-old female subject. A and B, ADC maps show multiple hypointensities scattered throughout the centrum semiovale at both time points, but there is a marked increase of hypointensity diffusely scattered throughout at 1 hour after acute alcohol consumption compared with before acute alcohol consumption. C and D, T2WI images show no visible changes in the centrum semiovale. E and F, Isotropic DWI images show an increase of hyperintensity diffusely scattered throughout the centrum semiovale at 1 hour after acute alcohol consumption compared with before acute alcohol consumption.
- Fig 3.
Graphs demonstrate the mean ADC of the high dose (A) and low dose (B), the FA of the high dose (C) and low dose (D) in the frontal lobe, and the BrAC values (E) for low and high groups in response to 2 doses at different time points.
Tables
- Table 1:
ADC values of the high-acute-alcohol-administration group at different time points in the human braina
Time Frontal White Matter Internal Capsule External Capsule Precentral Gyrus Postcentral Gyrus Thalamus Middle Cerebellar Peduncle Brain Stem Pre- 0.772 ± 0.621 0.716 ± 0.419 0.731 ± 0.288 0.707 ± 0.322 0.713 ± 0.414 0.769 ± 0.358 0.686 ± 0.305 0.720 ± 0.220 0.5 hr 0.753 ± 0.479 0.721 ± 0.392 0.747 ± 0.297 0.699 ± 0.500 0.715 ± 0.558 0.764 ± 0.297 0.674 ± 0.300 0.718 ± 0.218 1 hr 0.749 ± 0.334b 0.714 ± 0.442c 0.739 ± 0.346 0.704 ± 0.359 0.705 ± 0.420 0.737 ± 0.309b 0.648 ± 0.646b 0.704 ± 0.249 2 hr 0.752 ± 0.432b 0.722 ± 0.378c 0.742 ± 0.293 0.721 ± 0.589 0.694 ± 0.349 0.757 ± 0.351 0.641 ± 0.461b 0.707 ± 0.172 3 hr 0.757 ± 0.471 0.700 ± 0.394 0.734 ± 0.381 0.704 ± 0.405 0.697 ± 0.292 0.758 ± 0.206 0.646 ± 0.427b 0.721 ± 0.136 -
Note:—Pre- indicates Pre-acute alcohol administration.
-
↵a The numeric values presented are ADC ± SD for the high-dose group. ADC values are 10−3 mm2/s.
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↵b P < .01 was considered to indicate an obviously statistically significant difference.
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↵c P < .05 was considered to indicate a statistically significant difference.
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- Table 2:
ADC values of the low-acute-alcohol-administration group at different time points in the human braina
Time Frontal White Matter Internal Capsule External Capsule Precentral Gyrus Postcentral Gyrus Thalamus Middle Cerebellar Peduncle Brain Stem Pre- 0.761 ± 0.601 0.702 ± 0.353 0.732 ± 0.293 0.703 ± 0.408 0.709 ± 0.307 0.726 ± 0.285 0.710 ± 0.208 0.722 ± 0.065 0.5 hr 0.750 ± 0.262 0.703 ± 0.446 0.736 ± 0.339 0.710 ± 0.187 0.700 ± 0.412 0.718 ± 0.477 0.702 ± 0.245 0.714 ± 0.045 1 hr 0.737 ± 0.372b 0.682 ± 0.406 0.724 ± 0.225 0.699 ± 0.467 0.690 ± 0.379 0.708 ± 0.254 0.672 ± 0.320b 0.716 ± 0.442 2 hr 0.745 ± 0.578 0.666 ± 0.494 0.714 ± 0.316 0.694 ± 0.426 0.703 ± 0.374 0.709 ± 0.411 0.652 ± 0.536b 0.723 ± 0.016 3 hr 0.748 ± 0.479 0.680 ± 0.366 0.726 ± 0.240 0.702 ± 0.404 0.667 ± 0.321 0.710 ± 0.411 0.658 ± 0.538b 0.717 ± 0.262 - Table 3:
FA values of the high-acute-alcohol-administration groups at different time points in the human braina
Time Frontal White Matter Internal Capsule External Capsule Precentral Gyrus Postcentral Gyrus Thalamus Middle Cerebellar Peduncle Brain Stem Pre- 0.404 ± 0.082 0.585 ± 0.067 0.348 ± 0.049 0.335 ± 0.070 0.366 ± 0.083 0.283 ± 0.056 0.591 ± 0.041 0.537 ± 0.023 0.5 hr 0.445 ± 0.086b 0.595 ± 0.075 0.377 ± 0.053 0.359 ± 0.075 0.415 ± 0.097 0.301 ± 0.048 0.607 ± 0.046 0.531 ± 0.029 1 hr 0.438 ± 0.085c 0.599 ± 0.072 0.354 ± 0.059 0.356 ± 0.070 0.377 ± 0.088 0.297 ± 0.050 0.618 ± 0.064 0.522 ± 0.035 2 hr 0.444 ± 0.088b 0.598 ± 0.076 0.355 ± 0.059 0.346 ± 0.097 0.392 ± 0.069 0.316 ± 0.039c 0.627 ± 0.071 0.533 ± 0.033 3 hr 0.442 ± 0.079b 0.612 ± 0.052 0.357 ± 0.057 0.333 ± 0.059 0.396 ± 0.068 0.303 ± 0.046 0.600 ± 0.053 0.534 ± 0.014 - Table 4:
FA values of the low-acute-alcohol-administration groups at different time points in the human braina
Time Frontal White Matter Internal Capsule External Capsule Precentral Gyrus Postcentral Gyrus Thalamus Middle Cerebellar Peduncle Brain Stem Pre- 0.353 ± 0.112 0.534 ± 0.075 0.338 ± 0.056 0.360 ± 0.097 0.384 ± 0.102 0.280 ± 0.051 0.585 ± 0.058 0.542 ± 0.081 0.5 hr 0.453 ± 0.090b 0.588 ± 0.083 0.374 ± 0.040 0.339 ± 0.111 0.361 ± 0.093 0.301 ± 0.047 0.574 ± 0.038 0.545 ± 0.068 1 hr 0.382 ± 0.095 0.559 ± 0.096 0.350 ± 0.059 0.351 ± 0.088 0.374 ± 0.080 0.297 ± 0.056 0.578 ± 0.054 0.532 ± 0.094 2 hr 0.358 ± 0.094 0.524 ± 0.090 0.351 ± 0.044 0.352 ± 0.099 0.379 ± 0.095 0.282 ± 0.042 0.619 ± 0.080 0.523 ± 0.088 3 hr 0.397 ± 0.072 0.536 ± 0.040 0.394 ± 0.045 0.333 ± 0.094 0.344 ± 0.080 0.282 ± 0.044 0.593 ± 0.064 0.536 ± 0.092 - Table 5:
Correlation between DTI measurements (ADC and FA) and BrAC for the high- and low-alcohol doses in the FL and MCP at each time pointa
BrAC High Dose Low Dose ADC FA ADC FA r P r P r P r P 1-hr FL −0.526 .030b −0.089 .642 0.148 .436 −0.081 .671 1-hr MCP −0.681 .004b 0.316 .234 −0.277 .506 −0.438 .278 2-hr FL 0.142 .396 −0.129 .447 0.018 .889 0.077 .548 2-hr MCP −0.256 .338 0.253 .344 0.698 .054 0.364 .376 3-hr FL 0.216 .216 0.199 −.129 −0.565 .005b −0.098 .655 3-hr MCP 0.108 .690 0.224 .405 −0.746 .077 0.818b .047
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