Diffusion Tensor Imaging of Spinocerebellar Ataxias Types 1 and 2

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Fig 1.
Positioning of ROI for ADC and FA measurements.
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Fig 2.
Scatterplot of ADC (A) and FA (B) measurements. For each ROI, the columns are presented in the following order: controls, patients with SCA1, and patients with SCA2.

Table 1:

Clinical features of patients with SCA1 and SCA2

Features	SCA1 (n = 14)	SCA2 (n = 11)
CAG repeats (range)	40–58	35–47
Age at onset (years)	40.3 ± 10	35.9 ± 10
Disease duration (years)	8.2 ± 4.9	7.4 ± 4.4
Dysarthria (%)	100	87
Nystagmus (%)	21	0
Vertical gaze palsy (%)	43	73
Horizontal gaze palsy (%)	14	33
Slow saccades (%)	36	87
Increased bicep reflexes (%)	93	20
Increased patellar reflexes (%)	100	20
Lower limb spasticity (%)	71	13
Babinski sign (%)	79	60
Decreased vibration sense (%)	83	87
Dysphagia (%)	50	80
Amyotrophy (%)	7	0
Cognitive impairment (%)	7	13
Sphincteric disturbances (%)	29	47

Table 2:

Results from post hoc comparisons for the apparent diffusion coefficient (ADC) between controls and patients with SCA1 and SCA2

ADC	Controls	SCA1	SCA2	SCA1-controls	SCA2-controls	SCA1-SCA2
CST (cerebral peduncle)	0.70 ± 0.04	0.75 ± 0.08	0.82 ± 0.08	n.s.	^***	^**
CST (pons)	0.68 ± 0.05	0.71 ± 0.05	0.78 ± 0.06	n.s.	^***	^***
TPF	0.69 ± 0.04	0.72 ± 0.06	0.78 ± 0.09	n.s.	^***	^***
SCP	0.86 ± 0.05	0.88 ± 0.05	0.92 ± 0.06	n.s.	^**	^*
MCP	0.68 ± 0.04	0.81 ± 0.08	0.88 ± 0.12	^***	^***	^*
CWM	0.66 ± 0.04	0.78 ± 0.04	0.89 ± 0.11	^***	^***	^***

Note:—CST indicates corticospinal tract, TPF, transverse pontine fibers; SCP, superior cerebellar peduncles; MCP, middle cerebellar peduncles; CWM, cerebellar white matter; n.s., not significant.
Values are expressed as mean ± SD.
* P < .05,
** P < .01,
*** P < .001.

Table 3:

Results from post hoc comparisons for fractional anisotropy (FA) between controls and patients with SCA1 and SCA2

FA	Controls	SCA1	SCA2	SCA1-Controls	SCA2-Controls	SCA1-SCA2
CST (cerebral peduncle)	0.63 ± 0.06	0.53 ± 0.09	0.48 ± 0.07	^**	^***	^*
CST (pons)	0.47 ± 0.05	0.39 ± 0.09	0.38 ± 0.07	^**	^**	n.s.
TPF	0.47 ± 0.06	0.42 ± 0.09	0.34 ± 0.11	^*	^***	^***
SCP	0.48 ± 0.04	0.42 ± 0.05	0.43 ± 0.07	^**.	^*	n.s.
MCP	0.54 ± 0.07	0.44 ± 0.08	0.40 ± 0.12	^**	^***	n.s.
CWM	0.45 ± 0.05	0.30 ± 0.11	0.34 ± 0.10	^***	^***	n.s.

Note:—CST indicates corticospinal tract; TPF, transverse pontine fibers; SCP, superior cerebellar peduncles; MCP, middle cerebellar peduncles; CWM, cerebellar white matter; n.s., not significant.
Values are expressed as mean ± SD.
* P < .05,
** P < .01,
*** P < .001.