Article Figures & Data
Figures
- Fig 1.
Orbital images from a 36-year-old woman 1 year after right-sided optic neuritis. Diseased optic nerve indicated by arrowhead, and contralateral healthy optic nerve indicated by arrow.
A, Nondiffusion weighted (b = 0) image.
B, ADC map.
C, FSE image demonstrating high signal intensity lesion in the right optic nerve.
D, sTE fFLAIR image demonstrating right optic nerve atrophy.
- Fig 2.
Scatter graph showing ADCs for diseased optic nerves 1 year after acute optic neuritis, healthy contralateral optic nerves, and control optic nerves.
- Fig 3.
Association between logMAR visual acuity and diseased optic nerve ADC (rS = 0.73; P = .001).
- Fig 4.
Association between 1-year VEP central field amplitude and diseased optic nerve ADC (rS = −0.57, P = .021).
Tables
Variable Mean (×10−6 mm2/s) Within-Subject SD 95% Reference Rangea CV (%)b Reliability Coefficientc Analysis/re-analysis: Control mean (n = 10) 928 23 ±45 2.5 0.99 Diseased optic nerves (n = 16) 1324 97 ±189 7.3 0.94 Healthy contralateral optic nerves (n = 14) 990 31 ±61 3.2 0.96 Image/reimage: Control mean (n = 7) 946 95 ±186 10.0 0.58 a 1.96 × within-subject SD; 95% of measurements are expected to lie within this departure from the true value.
b CV, coefficient of variation.
c The proportion of total variance due to between-subject variation. Under assumptions that are plausible here, 1 minus this value is the proportion of variation due to measurement error.
- TABLE 2:
Association between diseased optic nerve ADC and clinical and electrophysiologic measurements
SRCC P Value logMAR visual acuity 0.73 0.001 30-2 Humphrey mean deviation (dB) −0.80 <0.001 FM 100 Hue square root of error score 0.83 <0.001 VEP whole-field amplitude (μV) −0.64 0.008 VEP whole-field latency (ms) 0.58 0.019 VEP central-field amplitude (μV) −0.57 0.021 VEP central-field latency (ms) 0.58 0.019 Note.—FM 100 Hue, Farnsworth Munsell 100 Hue test; SRCC, Spearman’s rank correlation coefficient; VEP = visual evoked potentials.
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