Neuroradiological Imaging and Neuropsychological Testing in Multiple Sclerosis
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* Ivan G. Ainyette
* Paola Bowers
* Hilda Llingüin

In the February 2000 issue of the *AJNR,* the article written by Rovaris et al (1) caught our attention. We admire the authors' use of neuropsychological tests for measuring cognitive functions in their study of multiple sclerosis. They seem to be aware of the sensitivity of neuropsychological tests in measuring cognition (2).

We also applaud the concept of incorporating comprehensive neuropsychological testing rather than using one or two for the research protocol.

To their credit, the authors not only cited research that confirmed a relationship with MR imaging, neuropsychological tests, and multiple sclerosis (3) but also data that did not (4).

We hope that the *AJNR* continues to publish research studies that incorporate neuroradiologic imaging and neuropsychological instruments.

## References

1.  Rovaris M, Filippi M, Minicucci L, et al. **Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis.** AJNR Am J Neuroradiol 2000;21:402-408
    
    [Abstract/FREE Full Text](http://www.ajnr.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo4OiIyMS8yLzQwMiI7czo0OiJhdG9tIjtzOjIyOiIvYWpuci8yMS84LzE1NjQuMy5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=) 

2.  Reitan RM, Wolfson D. ***Traumatic Brain Injury: Pathophysiology and Neuropsychological* *Evaluation*. .** Tucson, AZ: Neuropsychology Press 1986;
    
    

3.  Rao SM, Leo GJ, Haughton VM, St. Aubin-Faubert P, Bernardin L. **Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis.** Neurology 1989;39:161-166
    
    [Abstract/FREE Full Text](http://www.ajnr.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjg6IjM5LzIvMTYxIjtzOjQ6ImF0b20iO3M6MjI6Ii9ham5yLzIxLzgvMTU2NC4zLmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==) 

4.  Rovaris M, Filippi M, Falautano M, et al. **Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis.** Neurology 1998;50:1601-1608
    
    [Abstract/FREE Full Text](http://www.ajnr.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6OToibmV1cm9sb2d5IjtzOjU6InJlc2lkIjtzOjk6IjUwLzYvMTYwMSI7czo0OiJhdG9tIjtzOjIyOiIvYWpuci8yMS84LzE1NjQuMy5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=) 

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