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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging

Nodal Volume Reduction after Concurrent Chemo- and Radiotherapy: Correlation between Initial CT and Histopathologic Findings

Robert F. Labadie, Wendell G. Yarbrough, Mark C. Weissler, Harold C. Pillsbury and Suresh K. Mukherji
American Journal of Neuroradiology February 2000, 21 (2) 310-314;
Robert F. Labadie
aFrom the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
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Wendell G. Yarbrough
aFrom the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
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Mark C. Weissler
aFrom the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
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Harold C. Pillsbury
aFrom the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
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Suresh K. Mukherji
aFrom the Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
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    Fig 1. Representative CT scans (pretreatment [A]; post-treatment [B]) show the response to chemoradiation of a pathologically abnormal node (open arrow) and a normal node (closed arrow). The pathologically abnormal node shows a volume reduction of 84%, and the normal node shows a volume reduction of 98%. The extracapsular spread seen in the pathologically abnormal node in the pretreatment scan is not seen in the post-treatment scan

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    Fig 2. Volume reduction of lymph nodes in response to chemoradiation. A, A significant (P < .01) volume reduction of 91 ± 4% is seen for the pathologically abnormal nodes. B, Volume reduction in the normal nodes, 55 ± 21%, is not significant (P > .1). Note the different scales between the panels

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    Fig 3. Histopathologic findings of resected lymph nodes.

    A, Eighteen of 19 previously clinically positive lymph nodes show fibrosis and inflammation (original magnification, ×20).

    B, In the other node (one of 19), a small focus of squamous cell carcinoma is apparent (arrows) (original magnification, ×20).

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    HNSCC patient demographics, diagnosis, and disease-free state

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American Journal of Neuroradiology
Vol. 21, Issue 2
1 Feb 2000
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Nodal Volume Reduction after Concurrent Chemo- and Radiotherapy: Correlation between Initial CT and Histopathologic Findings
Robert F. Labadie, Wendell G. Yarbrough, Mark C. Weissler, Harold C. Pillsbury, Suresh K. Mukherji
American Journal of Neuroradiology Feb 2000, 21 (2) 310-314;
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Robert F. Labadie, Wendell G. Yarbrough, Mark C. Weissler, Harold C. Pillsbury, Suresh K. Mukherji
Nodal Volume Reduction after Concurrent Chemo- and Radiotherapy: Correlation between Initial CT and Histopathologic Findings
American Journal of Neuroradiology Feb 2000, 21 (2) 310-314;

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