Research ArticleBrain
Interscanner Variation in Brain MR Lesion Load Measurements in Multiple Sclerosis Using Conventional Spin-Echo, Rapid Relaxation-Enhanced, and Fast-FLAIR Sequences
Massimo Filippi, Maria A. Rocca, Claudio Gasperini, Maria P. Sormani, Stefano Bastianello, Mark A. Horsfield, Carlo Pozzilli and Giancarlo Comi
American Journal of Neuroradiology January 1999, 20 (1) 133-137;
Massimo Filippi
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Maria A. Rocca
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Claudio Gasperini
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Maria P. Sormani
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Stefano Bastianello
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Mark A. Horsfield
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Carlo Pozzilli
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.
Giancarlo Comi
aFrom the Neuroimaging Research Unit (M.F., M.A.R., M.P.S.) and Clinical Trials Unit (G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan; Departments of Neurology (C.G., C.P.) and Neuroradiology (S.B.), Università “La Sapienza,” Rome; Department of Neurology (C.G.), San Camillo Hospital, Rome; Unit of Clinical Epidemiology and Trials (M.P.S.), Institute for Cancer Research, Genoa, Italy; and Division of Medical Physics (M.A.H.), University of Leicester, Leicester, UK.

References
- ↵Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. . Ann Neurol 1996;39:6-16
- ↵
- ↵Stone LA, Albert PS, Smith ME, et al. Changes in the amount of diseased white matter over time in patients with relapsing-remitting multiple sclerosis. . Neurology 1995;45:1808-1814
- Evans AC, Frank JA, Antel J, Miller DH. The role of MRI in clinical trials of multiple sclerosis: comparison of image processing techniques. . Ann Neurol 1997;41:125-132
- ↵Filippi M, Horsfield MA, Adèr HJ, et al. Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. . Ann Neurol 1998;43:499-506
- ↵Filippi M, van Waesberghe JH, Horsfield MA, et al. Interscanner variation in brain MRI lesion load measurements in MS: implications for clinical trials. . Neurology 1997;49:371-377
- ↵Gawne-Cain ML, Webb S, Tofts P, Miller DH. Lesion volume measurement in multiple sclerosis: how important is accurate repositioning? . J Magn Reson Imaging 1996;6:705-713
- Filippi M, Marcianò N, Capra R, et al. The effect of imprecise repositioning on lesion volume measurements in patients with multiple sclerosis. . Neurology 1997;49:274-276
- Simon JH, Scherzinger A, Raff U, Li X. Lesion volume quantification in multiple sclerosis: computerized method and potential errors in serial study. . AJNR Am J Neuroradiol 1997;18:580-582
- Rovaris M, Filippi M, Calori G, et al. Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis: a comparison with conventional T2-weighted images. . J Neurol 1997;244:266-270
- ↵Thorpe JW, Halpin SF, MacManus DG, et al. A comparison between fast and conventional spin-echo in the detection of multiple sclerosis lesions. . Neuroradiology 1994;36:388-392
- ↵Yousry TA, Filippi M, Becker C, Horsfield MA, Voltz R. Comparison of MR pulse sequences in the detection of multiple sclerosis lesions. . AJNR Am J Neuroradiol 1997;18:959-963
- ↵Bastianello S, Bozzao A, Paolillo A, et al. Fast spin echo and fast fluid attenuated inversion-recovery versus conventional spin-echo sequences for quantification of multiple sclerosis lesions. . AJNR Am J Neuroradiol 1997;18:699-704
- Rovaris M, Yousry T, Calori G, Fesl G, Voltz R, Filippi M. Sensitivity and reproducibility of fast-FLAIR, FSE, and TGSE sequences for MRI assessment of brain lesion load in multiple sclerosis: a preliminary study. . J Neuroimaging 1997;7:98-102
- Filippi M, Horsfield MA, Bressi S, et al. Intra- and inter-observer agreement of brain MRI lesion volume measurements in multiple sclerosis: a comparison of techniques. . Brain 1995;118:1583-1592
- Filippi M, Horsfield MA, Rovaris M, et al. Intraobserver and interobserver variability in schemes for estimating volume of brain lesions on MR images in multiple sclerosis. . AJNR Am J Neuroradiol 1998;19:239-244
- ↵Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. . Ann Neurol 1983;13:227-231
- ↵Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. . Neurology 1996;46:907-911
- ↵Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). . Neurology 1993;33:1444-1452
- ↵Miller DH, Barkhof F, Berry I, Kappos L, Scotti G, Thompson AJ. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. . J Neurol Neurosurg Psychiatry 1991;54:683-688
- ↵Filippi M, Gawne-Cain ML, Gasperini C, et al. The effect of training and different measurement strategies on the reproducibility of brain MRI lesion load measurements in multiple sclerosis. . Neurology 1998;50:238-244
- ↵Bossi A, Milani S. Linear models for the analysis of variability in factorial designs: an application to anthropometric indicators. . Stat Med 1985;4:379-386
- ↵Efron B, Tibshirani R. An Introduction to the Bootstrap New York: Chapman & Hall; 1993
- ↵Bennett CA, Franklin NL. Statistical Analysis in Chemistry and the Chemical Industry New York: Wiley; 1954;367-368
- ↵Filippi M, Horsfield MA, Campi A, Mammi S, Pereira C, Comi G. Resolution-dependent estimates of lesion volumes in magnetic resonance imaging studies of the brain in multiple sclerosis. . Ann Neurol 1995;38:749-754
- Filippi M, Campi A, Dousset V, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. . Neurology 1995;45:478-482
- van Buchem MA, McGowan JC, Kolson DL, Polansky M, Grossman RI. Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. . Magn Reson Med 1996;36:632-636
- ↵Rydberg JN, Reiderer SJ, Rydberg CH, Jack CR. Contrast optimization of fluid-attenuated inversion recovery (FLAIR) imaging. . Magn Reson Med 1995;34:868-877
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Massimo Filippi, Maria A. Rocca, Claudio Gasperini, Maria P. Sormani, Stefano Bastianello, Mark A. Horsfield, Carlo Pozzilli, Giancarlo Comi
Interscanner Variation in Brain MR Lesion Load Measurements in Multiple Sclerosis Using Conventional Spin-Echo, Rapid Relaxation-Enhanced, and Fast-FLAIR Sequences
American Journal of Neuroradiology Jan 1999, 20 (1) 133-137;
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Interscanner Variation in Brain MR Lesion Load Measurements in Multiple Sclerosis Using Conventional Spin-Echo, Rapid Relaxation-Enhanced, and Fast-FLAIR Sequences
Massimo Filippi, Maria A. Rocca, Claudio Gasperini, Maria P. Sormani, Stefano Bastianello, Mark A. Horsfield, Carlo Pozzilli, Giancarlo Comi
American Journal of Neuroradiology Jan 1999, 20 (1) 133-137;
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