Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner ======================================================================================================================================================================================================================= * Dipti Thakkar * Shalini Paliwal * Bhushan Dharmadhikari * Siyu Guan * Lillian Liu * Shreya Kar * Nikhil K Tulsian * Joshua J Gruber * Leah DiMascio * Konrad H Paszkiewicz * Piers J Ingram * Jerome D Boyd-Kirkup